Objective: To evaluate the efficacy of pallidal deep brain stimulation (DBS) using eight contacts electrodes with multiple-source current steering for motor improvement in patients with advanced parkinson’s disease.

Background: DBS is established symptomatic treatment for advanced Parkinson’s disease. Although eight contacts with multiple-source current steering DBS devices were widely used worldwide, the evidences were limited mainly to subthalamic DBS.

Methods: We performed a single center, non-randomized, open-label study of a DBS device. Parkinson disease patients who had medically reflected dyskinesias, motor fluctuations, and who had a contraindication for subthalamic DBS due to psychiatric complications or cognitive functions were eligible for this study. The endpoint was set to the improvement of UPDRS-III scores from baseline, and evaluated in 2, 12, 24 weeks after DBS operation.

Results: 21 patients received a bilateral Pallidal DBS with this device. 19 of 21 patients meet the inclusion criteria. The mean UPDRS-III score at baseline was 49.4 (36-84). Motor improvement at 2, 12, 24 weeks were -55.7%, -53.2%, -51.2%. Mean levodopa equivalent daily dose was 980mg at baseline, and 670mg, 710mg, 725mg at 2, 12, 24 weeks after DBS. One patients received removal of the device due to infection at four weeks after implantation. Four patients experienced adverse effects such as stimulation evoked dystonia, and speech problems.

Conclusions: Pallidal DBS with eight contacts, multiple-source steering for parkinson’s disease well suppressed motor symptoms of advanced parkinson’s disease patients. 

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MDS Abstracts - https://www.mdsabstracts.org/abstract/eight-contacts-with-multiple-source-current-steering-in-pallidal-deep-brain-stimulation-for-parkinsons-disease-a-non-randomized-single-center-open-lavel-study/