Session Information
Date: Monday, June 20, 2016
Session Title: Epidemiology
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: (1)To study what comorbid conditions were present at baseline and 3 years later in a cohort of Spanish PD patients and (2) to analyze the role of comorbidity as predictor of mortality.
Background: Parkinson´s disease (PD) is accompanied by significant comorbidity and that both the extent and type of comorbidity vary as a function of PD duration and age at symptoms onset. Comorbidity should be taken into consideration in the management of the disease.
Methods: One hundred and forty nine non-demented PD patients (57 % males; 70.9 ± 8.6 years old) were included in this 36 months follow-up, longitudinal, monocenter, evaluation study. The International Classification of Diseases, Tenth Revision (ICD-10), Charlson Index (CI), Comorbidity-Polypharmacy Score (CPS) and Elixhauser Comorbidity Measure (ECM) were used to asses comorbidity at baseline and at 3 years.
Results: Seventeen patients died and 8 cases were loss to follow-up. Diseases of the circulatory system (ICD-10/chapter-IX) and endocrine, nutritional and metabolic diseases (ICD-10/chapter-IV) were the most frequent at baseline (53.7% and 51.7%, respectively) and at 3 years (57.3% and 58.1%, respectively). According to ECM, hypertension was the most frequent comorbidity at baseline and at 3 years (41.6% and 46%, respectively). A significant increase in comorbidity was observed at 3 years (n=124): ICD-10 (total number of comorbidities), 5.9 ± 3.8 vs 4.1 ± 1.9 (p<0.001); CI, 0.9 ± 1.4 vs 0.5 ± 0.9 (p<0.001); CPS, 12.4 ± 5.3 vs 9.9 ± 4.1 (p<0.001). Total number and severity of comorbidities at baseline were higher in patients who died (n=141): ICD-10, 5.7 ± 3.3 vs 4.1 ± 1.9 (p=0.006); CI, 1.4 ± 1.6 vs 0.5 ± 0.9 (p=0.001); CPS, 12.7 ± 6.1 vs 9.9 ± 4.1 (p=0.017). Comorbidity was a predictor of death after other covariates adjustment: ICD-10 (total number of comorbidities), hazard ratio 1.261 (95% confidence interval, 1.043-1.524; p=0.017); CI, hazard ratio 1.454 (95% confidence interval, 1.043-2.027; p=0.027).
Conclusions: Comorbidity is frequent in PD patients, increases significantly over time and predicts mortality.
To cite this abstract in AMA style:
D. Santos García, E. Suarez Castro, I. Expósito, T. de Deus, C. Tuñas, D. Núñez Arias, Á. Aneiros, M. López Fernández, J. Naveiro, J. Abella, M.A. Llaneza, V. Vilas, M. Macías. Comorbid conditions associated with Parkinson´s disease: A longitudinal study [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/comorbid-conditions-associated-with-parkinsons-disease-a-longitudinal-study/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/comorbid-conditions-associated-with-parkinsons-disease-a-longitudinal-study/