Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To assess the surgical morbidity and comorbidity in 140 consecutive patients with various disease entities of movement disorders, epilepsy and obsessive-compulsive disorders that underwent deep brain stimulation (DBS) in a single DBS center of Taiwan.
Background: The benefit of DBS therapy in treating neurological diseases is well known. However, The morbidity and comorbidity of DBS in long-term follow-up should be investigated. The data will be used in clinical decision in performing DBS surgery.
Methods: From Feb 2002 to Feb 2015, a total of 140 patients in our institute were included for analyzed retrospectively. All patients underwent standard DBS procedures with intra-operative microelectrode recordings, and were followed for at lease 6 months.
Results: Among surgical morbidity, symptomatic hemorrhage 2.8%(4/140), lead mal-positioned 3.6%(5/140) and hardware infection 1.4%(2/140). There had no surgical related mortality. Post-operative morbidity within 6 months was 40.7% (57/140), which included: weight gain (more than 5 kg) 28.6% (40/140), mania/hypophonia 8.6%(12/140), transient confusion 7.9% (11/140), depression 4.3%(6/140) and pulmonary edema 2.1%(3/140). Stimulation related morbidity was 47.8% (66/140), which included hypophonia 18.1%(n=25/138), dyskinesia 13.8%(19/138), dysarthria 13.8%(19/138), sialorrhea 12.3%(17/138) and decreased memory 11.6% (16/138). The comorbidity of these patients within the follow-up period up to 13 years was 73%(86/118, loss follow=20), which included patients who expired, demented, received bone/spine surgery and diagnosed as cancer.
Conclusions: The associated morbidity and comorbidity is significant in DBS patients. Stimulation related morbidity was high, nevertheless, most of these was transient, and could be improved after change in stimulation parameters. Though the incidence is low, intracranial hemorrhage remains as a high risk in DBS surgery.
To cite this abstract in AMA style:
S.Y. Chen, Y.H. Pan, S.H. Lin. Morbidity and comorbidity of deep brain stimulation for Parkinson’s disease – A thirteen-years retrospective cohort study [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/morbidity-and-comorbidity-of-deep-brain-stimulation-for-parkinsons-disease-a-thirteen-years-retrospective-cohort-study/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/morbidity-and-comorbidity-of-deep-brain-stimulation-for-parkinsons-disease-a-thirteen-years-retrospective-cohort-study/