Objective: In this study we tried to determine  the TRODAT SPECT findings in EOPD  as compared to LOPD.

Background: 99mTc-TRODAT-1, which binds to the dopamine transporter, could be used to image the dopaminergic system and diagnosis of Parkinson’s disease (PD). PD can be classified into two groups: late-onset Parkinson’s disease (LOPD) and early onset Parkinson’s disease (EOPD) that occurs in early life.

Methods: Fifteen patients were studied. The diagnosis of PD was defined by clinical criteria based on UK Parkinson’s Disease Society Brain Bank criteria. Six patients whose age at onset of PD were younger than 50 were defined as patients with EOPD and 9 patients with older than 50 years were defined as patients with LOPD. All patient underwent   99mTc-TRODAT Brain SPECT.

Results: No significant difference was noticed between EOPD and LOPD in disease stage and symptoms. In visual analysis, 20 (66.67%) caudate nucleuses had decreased tracer uptake while all 30 (100%) putamens had decreased or absent tracer uptake. No significant difference between EOPD and LOPD was noticed in visual analysis. Striatum, Caudate and Putamen uptake ratio were calculated. No significant difference was noticed between EOPD and LOPD in these ratios.  However there was significant difference in visual analysis (tracer uptake) as well as in uptake ratio between putamen and caudate nucleuses in both groups (P=0.001).

Conclusions: 99mTc-TRODAT-1 SPECT imaging showed lower presynaptical dopaminergical terminals density in both EOPD and LOPD. We didn’t find in TRODAT uptake between two groups. Putamen showed more involvement and diminished TRODAT uptake.  

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MDS Abstracts - https://www.mdsabstracts.org/abstract/99mtc-trodat-1-spect-imaging-in-early-and-late-onset-parkinsons-disease/