Session Information
Date: Tuesday, June 21, 2016
Session Title: Restless legs syndrome and other sleep disorders
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigated if RLS is increased in familial amyloid polyneuropathy related to transthyretin (TTR-FAP) and to identify factors associated with RLS in this population.
Background: The relationship between restless legs syndrome (RLS) and peripheral neuropathy remains unclear.
Methods: RLS frequency was compared between TTR-FAP patients and controls. Secondly, TTR-FAP patients with and without RLS were compared regarding demographic and clinical characteristics.
Results: RLS frequency was significantly increased in TTR-FAP, with 18/98 (18.4%) cases contrasting with 5/104 (4.8%) controls (p-value 0.002). This difference remained significant after adjusting for confounders. In TTR-FAP patients, female sex (p-value 0.037), obesity (p-value 0.036) and weight excess (p-value 0.048) were associated with RLS, contrary to other classical RLS risk factors.
Conclusions: RLS frequency is increased in TTR-FAP, thus supporting an association between RLS and neuropathy. This may represent a peripheral pathway in RLS pathogenesis. Furthermore, our results suggest that female sex and obesity/weight excess may be risk factors for RLS development among TTR-FAP patients.
To cite this abstract in AMA style:
T. Teodoro, P. Viana, D. Abreu, I. Conceição, R. Peralta, J.J. Ferreira. A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/a-peripheral-pathway-to-restless-legs-syndrome-clues-from-familial-amyloid-polyneuropathy/. Accessed July 9, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/a-peripheral-pathway-to-restless-legs-syndrome-clues-from-familial-amyloid-polyneuropathy/