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A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy

T. Teodoro, P. Viana, D. Abreu, I. Conceição, R. Peralta, J.J. Ferreira (Lisboa, Portugal)

Meeting: 2016 International Congress

Abstract Number: 941

Keywords: Peripheral neuropathy, Restless legs syndrome(RLS): Etiology and Pathogenesis, Restless legs syndrome(RLS): Pathophysiology

Session Information

Date: Tuesday, June 21, 2016

Session Title: Restless legs syndrome and other sleep disorders

Session Time: 12:30pm-2:00pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To investigated if RLS is increased in familial amyloid polyneuropathy related to transthyretin (TTR-FAP) and to identify factors associated with RLS in this population.

Background: The relationship between restless legs syndrome (RLS) and peripheral neuropathy remains unclear.

Methods: RLS frequency was compared between TTR-FAP patients and controls. Secondly, TTR-FAP patients with and without RLS were compared regarding demographic and clinical characteristics.

Results: RLS frequency was significantly increased in TTR-FAP, with 18/98 (18.4%) cases contrasting with 5/104 (4.8%) controls (p-value 0.002). This difference remained significant after adjusting for confounders. In TTR-FAP patients, female sex (p-value 0.037), obesity (p-value 0.036) and weight excess (p-value 0.048) were associated with RLS, contrary to other classical RLS risk factors.

Conclusions: RLS frequency is increased in TTR-FAP, thus supporting an association between RLS and neuropathy. This may represent a peripheral pathway in RLS pathogenesis. Furthermore, our results suggest that female sex and obesity/weight excess may be risk factors for RLS development among TTR-FAP patients.

To cite this abstract in AMA style:

T. Teodoro, P. Viana, D. Abreu, I. Conceição, R. Peralta, J.J. Ferreira. A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/a-peripheral-pathway-to-restless-legs-syndrome-clues-from-familial-amyloid-polyneuropathy/. Accessed June 18, 2025.
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