Objective: We aimed to analyze the mortality and prevalence of movement disorders in the United States from 1999 to 2020 to compare disparities among various sociodemographic groups.

Background: Movement disorders are a group of neurological pathologies defined by abnormal voluntary or involuntary movements. These illnesses, which include Parkinson’s disease and essential tremor, present significant challenges to public health due to their progressive nature and related comorbidities.

Method: Death Certificates from the CDC Wonder (Centres for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database were examined from 1999 to 2020 for MD (ICD-10 Codes: G20-G25). Age-adjusted mortality rates (AAMRs) per 1,000,000 people and annual percent change (APC) were stratified by age groups, sex, race, census region, urbanization, and state. The Joinpoint Regression Program calculates MD’s Annual Percent Change (APC) trends.

Results: The AAMRs for MD had two significant trends, there was an initial period of stability from 1999 to 2014 (APC: -0.58 CI: -1.08 to -0.07) followed by a rise from to 2020 (APC: 5.57 CI: 3.90 to 7.26). MD-related deaths were concentrated in the 80+ population (Overall Crude Rate: 294.54 CI: 294.56 to 296.51). Males had higher AAMRs than females (Overall AAMR, Males: 18.49 CI: 18.44 to 18.54; Females: 8.34 CI: 8.31 to 8.36). Both White and Black/African Americans had similar trends for AAMRs, but African Americans had a steady rise in AAMRs(APC: 1.21 CI: 0.58 to 1.84), White Americans had a slow decline till 2018 (APC: -0.18 CI: -0.42 to 0.06) followed by a rapid rise (APC: 8.27 CI: 0.73 to 16.37). MD-related mortality was highest among White Americans (Overall AAMR: 13.04 CI: 13.01 to 13.07). The trends in MD-related AAMR for geographical variables were similar to the overall trend. Midwestern and rural United States were hotspots for MD-related mortality (Overall AAMR, Midwest: 13.44 CI: 13.38 to 13.49; Rural US: 13.11 CI: 13.02 to 13.19). Nebraska, Minnesota, South Dakota, Iowa, Oklahoma, and Utah come in the top 90^th percentile.

Conclusion: Mortalities due to MD have risen sharply post-2014; in this study, we aim to underline the need to identify the cause of this rapid rise. Males and White Americans were found to be the most at-risk groups. Geographical hotspots were also identified to formulate targeted interventions for these populations better.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/abstract-trends-in-movement-disorders-related-death-in-the-united-states-from-1999-to-2020/