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Acute chorea secondary to cephalosporin

BED. Ines, BRA. Zeineb, MAN. Malek, ZAO. Jamel, MRI. Ridha (Tunis, Tunisia)

Meeting: 2019 International Congress

Abstract Number: 302

Keywords: Choreoathetosis

Session Information

Date: Monday, September 23, 2019

Session Title: Choreas (Non-Huntington’s Disease)

Session Time: 1:45pm-3:15pm

Location: Les Muses, Level 3

Objective: To report a case of acute chorea induced by ceftriaxone and to explain neurotoxicity of antibiotics.

Background: B Chorea was classically described in patients under neuropsychiatric drugs. Recently, some antibiotics as ß-lactam had been incriminated in movement disorders.

Method: Methods:  medical teaching case report  Case report: We report a 65-year-old man  with renal failure who  was prescribed ceftriaxone 1.5 g/day intravenously for the treatment of acute upper urinary infection.  Four days after, he developed drowsiness associated to chorea. Magnetic resonance image of the brain, cerebro-spinal fluid were normal. Dosage of ceftriaxone was high in blood.  Withdrawal of antibiotics, complete resolution of the movement disorders and the drowsiness  was obtained in two days.Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure.  Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.

Results: Case report: We report a 65-year-old man  with renal failure who  was prescribed ceftriaxone 1.5 g/day intravenously for the treatment of acute upper urinary infection.  Four days after, he developed drowsiness associated to chorea. Magnetic resonance image of the brain, cerebro-spinal fluid were normal. Dosage of ceftriaxone was high in blood.  Withdrawal of antibiotics, complete resolution of the movement disorders and the drowsiness  was obtained in two days. Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure.  Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.

Conclusion: Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure.  Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.

To cite this abstract in AMA style:

BED. Ines, BRA. Zeineb, MAN. Malek, ZAO. Jamel, MRI. Ridha. Acute chorea secondary to cephalosporin [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/acute-chorea-secondary-to-cephalosporin/. Accessed July 11, 2025.
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