Session Information
Date: Monday, September 23, 2019
Session Title: Choreas (Non-Huntington’s Disease)
Session Time: 1:45pm-3:15pm
Location: Les Muses, Level 3
Objective: To report a case of acute chorea induced by ceftriaxone and to explain neurotoxicity of antibiotics.
Background: B Chorea was classically described in patients under neuropsychiatric drugs. Recently, some antibiotics as ß-lactam had been incriminated in movement disorders.
Method: Methods: medical teaching case report Case report: We report a 65-year-old man with renal failure who was prescribed ceftriaxone 1.5 g/day intravenously for the treatment of acute upper urinary infection. Four days after, he developed drowsiness associated to chorea. Magnetic resonance image of the brain, cerebro-spinal fluid were normal. Dosage of ceftriaxone was high in blood. Withdrawal of antibiotics, complete resolution of the movement disorders and the drowsiness was obtained in two days.Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure. Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.
Results: Case report: We report a 65-year-old man with renal failure who was prescribed ceftriaxone 1.5 g/day intravenously for the treatment of acute upper urinary infection. Four days after, he developed drowsiness associated to chorea. Magnetic resonance image of the brain, cerebro-spinal fluid were normal. Dosage of ceftriaxone was high in blood. Withdrawal of antibiotics, complete resolution of the movement disorders and the drowsiness was obtained in two days. Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure. Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.
Conclusion: Conclusion: ß-lactam antibiotics induce neurological hyperexcitability disorders by glutamate excess in the striatum and cerebral cortex, specially patients with renal failure. Movement disorders could appear. Adjustment of these antibiotics in the patients with failure renal clearance is recommended.
To cite this abstract in AMA style:
BED. Ines, BRA. Zeineb, MAN. Malek, ZAO. Jamel, MRI. Ridha. Acute chorea secondary to cephalosporin [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/acute-chorea-secondary-to-cephalosporin/. Accessed May 24, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/acute-chorea-secondary-to-cephalosporin/