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Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Alpha-synuclein levels and dimerization in erythrocytes of Parkinson’s disease patients

N. Papagiannakis, C. Koros, M. Stamelou, A.M. Simitsi, M. Maniati, R. Antonelou, D. Papadimitriou, G. Dermentzaki, M. Moraitou, H. Michelakakis, L. Stefanis (Chaidari, Greece)

Meeting: 2016 International Congress

Abstract Number: 626

Keywords: Aging

Session Information

Date: Tuesday, June 21, 2016

Session Title: Parkinson's disease: Genetics

Session Time: 12:30pm-2:00pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To identify possible differences in monomeric/dimeric α-synuclein levels in erythrocytes derived from PD patients from different genetic backgrounds, and check for potential links between α-synuclein levels and clinical or cognitive characteristics of PD patients.

Background: Variations of α-synuclein levels or species have been reported in plasma and cerebrospinal fluid from Parkinson’s disease (PD) patients.

Methods: Levels of monomeric and dimeric α-synuclein were assessed in PD patients from genetically undetermined background (n=56), α-synuclein (G209A/A53T, n=12) or glucocerebrosidase mutation carriers (n=20) and age-/sex-matched healthy controls (n=54) using Western immunoblots of lysates derived from erythrocyte membranes.

Results: A statistically significant increase in α-synuclein dimer levels and in the dimer to monomer ratio was found in genetically undetermined and glucocerebrosidase mutation carrier PD patients compared to healthy controls. No difference was found in α-synuclein monomer levels of the above categories or in monomer/dimer levels of α-synuclein mutation carriers. A positive correlation was found between age and the dimer to monomer ratio in genetically undetermined PD patients (r=0.338, P=0.028).

Conclusions: The increased α-synuclein dimer levels are suggestive of an apparent systemic dysfunction causing the dimerization, and potentially oligomerization, of α-synuclein in genetically undetermined and glucocerebrosidase mutation carriers and it may serve as a potentially useful peripheral biomarker for PD.

To cite this abstract in AMA style:

N. Papagiannakis, C. Koros, M. Stamelou, A.M. Simitsi, M. Maniati, R. Antonelou, D. Papadimitriou, G. Dermentzaki, M. Moraitou, H. Michelakakis, L. Stefanis. Alpha-synuclein levels and dimerization in erythrocytes of Parkinson’s disease patients [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/alpha-synuclein-levels-and-dimerization-in-erythrocytes-of-parkinsons-disease-patients/. Accessed July 15, 2025.
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