Session Information
Date: Wednesday, June 22, 2016
Session Title: Huntington's disease
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: This study aims to assess the functional integrity of the cerebello-thalamo-cortical (CTC) pathway in patients with Huntington’s disease (HD) through transcranial magnetic stimulation (TMS).
Background: Recent anatomical and histopathological findings suggest cerebellar involvement in HD pathophysiology. However, the functional significance of these findings remain elusive, especially that related to the control of movements.
Methods: Ten patients with EH and 10 unrelated healthy individuals, matched to patients in age and gender, were studied. The cerebellar brain inhibition (CBI) protocol was used to assess the cerebellar inhibition over the motor evoked potential (MEP). Effects of continuous theta burst stimulation (cTBS) applied over the cerebellum on cortical excitability and inhibition was assessed, as a measure of cerebellar plasticity.
Results: Patients with EH showed reduced MEP inhibition during the CBI protocol. After cTBS, cortical excitability and inhibition measures were not significantly affected as opposed to the effect of this stimulation had in healthy subjects.
Conclusions: These results suggest an alteration in the CTC pathway in patents with EH. It is thus necessary new studies assessing the clinical impact of these neurophysiological findings.
Yes
To cite this abstract in AMA style:
J.F. Martín-Rodríguez, M. Gómez-Crespo, M.T. Cáceres-Redondo, L. Vargas-González, F.J. Palomar, P. Porcacchia, P. Álvarez de Toledo, J.M. Oropesa-Ruiz, F. Carrillo, I. Huertas-Fernández, S. Jesús, P. Mir. Altered cerebello-thalamo-cortical pathway in Huntington’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/altered-cerebello-thalamo-cortical-pathway-in-huntingtons-disease/. Accessed July 12, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/altered-cerebello-thalamo-cortical-pathway-in-huntingtons-disease/