Category: Parkinson's Disease: Non-Motor Symptoms
Objective: We aim to use objective polysomnography to analyze the relationship between dyskinesia and sleep structure in patients with Parkinson’s disease.
Background: Levodopa is an effective drug for the Parkinson’s disease. At present, it is known that there is a certain relationship between dyskinesia and sleep.Previous studies have confirmed that Parkinson’s disease (PD) patients with dyskinesia have worse subjective sleep quality, but there are few related clinical studies.
Method: 122 patients with Parkinson’s disease from the Second Affiliated Hospital of Soochow University were included. According to the score of the 32nd item of UPDRS IV, the patients were divided into 2 groups: dyskinesia group (DYS, n=27), without dyskinesia group (non-DYS, n=95). The demographic information was collected. Polysomnography was used to record sleep information.85 patients with complete polysomnography (PSG) EEG data were divided into DYS group (n=23) and non-DYS group (n=62). We measured the demographic characteristics of the two groups and the differences in EEG Spectral density in each frequency range.
Results: Compared with the non-DYS group, the DYS group had more women, longer disease duration, higher levodopa equivalent dose, and a significantly higher proportion of NREM sleep.After adjusting for confounding factors, the proportion of NREM sleep is an independent risk factor for the occurrence of dyskinesia (OR 1.141, 95% CI 1.024-1.273, p =0.017). In addition, compared with patients in the non-DYS group, patients in the DYS group had lower frontal slow-wave EEG spectral density during NREM sleep all night. At the same time, it was also observed that patients in the DYS group had no significant SWA spectral density downscale during NREM sleep. After adjusting for confounding factors, the logistic regression analysis showed that low-frequency (0.5-2hz) SWA changes in the frontal area were independently associated with dyskinesia (OR 0.58; 95% CI 0.376-0.894, p =0.014).
Conclusion: This study verifies the conclusions of previous studies, revealing that there is disorder in sleep structure and EEG in PD patients with dyskinesia. It is important to pay attention to the sleep quality of patients with Parkinson’s disease with dyskinesia, especially for the patients who had higher proportion of NREM and whose frontal lobe channel SWA does not change significantly during NREM sleep throughout the night.
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To cite this abstract in AMA style:YM. Wang, CJ. Mao. Analysis of Sleep Structure and EEG Characteristics of Patients with Dyskinesia in Parkinson’s Disease [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/analysis-of-sleep-structure-and-eeg-characteristics-of-patients-with-dyskinesia-in-parkinsons-disease/. Accessed December 2, 2023.
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