Objective: The objective of this study is to assess raphe nucleus echo whether can be used as a means to distinguish endogenous and reactive depression/anxiety, so as to provide some reference value.

Background: Neurological disorders are often accompanied by depression/anxiety and the mechanism is complex.Studies have found that depression/anxiety is divided into endogenous and reactive^[1], and there are significant differences between the two in response to medication.At present,no effective means for identification.

Method: Part One: 48 inpatients admitted to the Department of Neurology were continuously enrolled. They were evaluated by HAMD and HAMD and the performed transcranial ultrasound detection of raphe nucleus.Draw the ROC curve, and the score of HAMD and HAMA was obtained when the raphe nucleus was predicted to be positive.Part Two: 58 inpatients admitted to the Department of Neurology were successively enrolled.Divided into the raphe nucleus positive group and raphe nucleus negative group, and sex, age ,education level,MMSE, MoCA to each group was collected. High Performance Liquid Chromatography was used to determine plasma concentrations of monoamine neurotransmitters in the peripheral blood of subjects, and the differences between the two groups were analyzed and compared.

Results: Part One: 1.HAMD score and HAMA score in BR+ group were significantly higher than those in BR- group, with statistical significance. 2.The best cutoff value of BR+ for predicting depression was 11.5 points.The best cutoff value for predicting anxiety was 18.5 points .Part Two: 1.The mean age of BR+ group (66.33±8.79) was higher than that of BR- group (59.32±8.39), and the difference was statistically significant.2.There was statistically significant difference in temporal orientation in MMSE between BR+ group and BR- group. 3.There was no significant difference in monoamine neurotransmitter concentration between BR+ group and BR- group.4.Age and MMSE (temporal orientation) were included into the Logistic regression equation, and the results showed that age and MMSE (temporal orientation) were independent risk factors for BR+.

Conclusion: 1.Raphe nucleus echo can be used as a means of early screening depression/anxiety. 2.Age and MMSE (temporal directivity) scores were associated with BR+.3.In this study, no correlation between plasma monoamine neurotransmitters and changes in raphe nucleus echo.

References: [1] Mizushima Jin,Sakurai Hitoshi,Mizuno Yuya et al. Melancholic and reactive depression: a reappraisal of old categories.[J] .BMC Psychiatry, 2013, 13: 311.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/analysis-of-the-correlation-between-the-raphe-nucleus-echo-and-neurological-diseases-with-depression-anxiety/