Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: The aim of this study was to examine the potential association between solvents, welding fumes and SNPs and risk of developing PD.
Background: The development of Parkinson’s disease significantly increased in the exposure of the human population to environmental contaminants. Industry uses the fuels, paints, printing inks, degreasers and cleaning products. Long term exposures might be associated with neurodegenerative diseases, such as Parkinson’s disease (PD).
Method: 100 occupational organic solvents and welding fumes exposed subjects and 100 controls was used (age and sex matched). Blood samples were collected from the study subjects, occupational history and daily life information of cases and controls were collected in hospital. Exposures to aromatic solvents and welding fumes were estimated using self-reported information on welding and painting activities. Lymphocytes were cultured the standard procedure and SNPs were analysed through the sequencing and interpreted.
Results: Exposures were increased chromosome aberrations when compared to controls. Furthermore, higher aberrations were observed in the chromosomes of the tobacco exposures and welders when compared to the non-smoking welders as well as controls. The PARK13, LRRK2 and CAST gene SNPs were analysed and a novel SNPs were found in tobacco exposures and welders when compared to the non-smoking welders somewhat PD risk was found in the tobacco exposures and welders painting workers.
Conclusion: Toxic compounds can result in a spectrum development of PD or related disorders. Metal compounds should be considered as a warning suggestion of potentially unfavourable genetic and somatic effects in humans. Malfunction of this system may lead to development of cancer and other genetic diseases. Toxicant exposures were associated with Parkinsonism. Many industrial processes such as dry cleaning, was a risk factor for parkinsonism. After occupational exposure to organic solvents, very limited role of genetic polymorphism was investigated in modulating the PD risk, but the combined effect of these variants may interact to increase the risk of PD.
To cite this abstract in AMA style:
K. Kalimuthu, R. Ramachndran, A. Arulsamy, S. Savariar. Assessment of occupationally exposed organic solvents and welding fumes induced DNA damage and SNPs (PARK13, LRRK2 and CAST gene) and risk of Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/assessment-of-occupationally-exposed-organic-solvents-and-welding-fumes-induced-dna-damage-and-snps-park13-lrrk2-and-cast-gene-and-risk-of-parkinsons-disease/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/assessment-of-occupationally-exposed-organic-solvents-and-welding-fumes-induced-dna-damage-and-snps-park13-lrrk2-and-cast-gene-and-risk-of-parkinsons-disease/