Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate the correlation between clinical features and pre- and post-synaptic dopaminergic dysfunction in patients with multiple system atrophy (MSA).
Background: Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disorder, which is clinically characterized by a combination of parkinsonism, cerebellar ataxia, pyramidal features, and autonomic dysfunction. MSA patients show considerable heterogeneity in clinical features, including parkinsonism and their levodopa responsiveness that is presumably related to nigrostriatal neuropathology.
Methods: We retrospectively analyzed clinical data of 102 MSA patients who underwent both [18F]-FP-CIT PET and [18F]-FDG PET. The tracer uptake of the striatum in [18F]-FP-CIT PET and glucose metabolism of the striatum in [18F]-FDG PET were visually analyzed and categorized the findings into predominant presynaptic (MSA-SNpc) and postsynaptic (MSA-STR) dopaminergic dysfunction according to the predominant imaging abnormalities between the pathological features of [18F]-FP-CIT PET and [18F]-FDG PET. Clinical features of MSA patients were compared with the findings of [18F]-FP-CIT PET and [18F]-FDG PET.
Results: Levodopa responsiveness and motor fluctuation were significantly more prevalent in patients with MSA-SNpc (N = 34) than those with MSA-STR (N = 21) (P < 0.001 and P = 0.01, respectively). Postural tremor was significantly more frequent in patients with MSA-STR than those with MSA-SNpc (P = 0.04). The proportion of clinical subtypes of MSA-Parkinsonian type (MSA-P) and MSA-cerebellar type (MSA-C) was not different between patients with MSA-SNpc and those with MSA-STR. There was no difference of age at onset of MSA, disease duration, mini-mental status examination scores, and the severity of parkinsonism, cerebellar ataxia, pyramidal signs, and autonomic dysfunctions between patients with MSA-SNpc and those with MSA-STR.
Conclusions: MSA-SNpc patients showed better levodopa responsiveness, more frequent motor fluctuation, and less frequent postural tremor compared with MSA-STR patients. Our findings may provide useful clinical imaging information for the management of clinically heterogeneous MSA patients.
To cite this abstract in AMA style:
H.S. Ryu, M. Oh, M.J. Kim, S. You, Y.J. Kim, J. Kim, K. Kim, H. Moon, J. Oh, J.S. Kim, S.J. Chung. Association between clinical features and pre- and post-synaptic dopaminergic dysfunction in multiple system atrophy: [18F]-FP-CIT PET and [18F]-FDG PET analyses [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/association-between-clinical-features-and-pre-and-post-synaptic-dopaminergic-dysfunction-in-multiple-system-atrophy-18f-fp-cit-pet-and-18f-fdg-pet-analyses/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-between-clinical-features-and-pre-and-post-synaptic-dopaminergic-dysfunction-in-multiple-system-atrophy-18f-fp-cit-pet-and-18f-fdg-pet-analyses/