Category: Parkinson's Disease: Cognitive functions
Objective: This study aims to investigate the association between comprehensive blood lipid biomarkers and Parkinson’s disease (PD).
Background: Studies have shown that the serum levels of lipid markers were reduced in PD patients compared to non-PD subjects. Mild cognitive impairment (MCI) is commonly present in PD patients even at the time of diagnosis. It was previously reported that higher triglyceride(TG) level is significant associated with PD-MCI. In view of the potential neuroprotective effects of lipids in PD and limited evidence in this field, we conducted a cross-sectionals study to examine the association between lipids and PD and further explored the relationship between lipids and PD-MCI.
Method: A total of 205 PD patients and 102 non-PD subjects were included from Early Parkinson’s disease Longitudinal Singapore (PALS) cohort. We investigated 6 serum lipid biomarkers including total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1(Apo A1), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B). PD patients were further classified into mild cognitive impairment (MCI) and normal cognition (NC) subgroups. We conducted a cross-sectionals study to examine the association between lipids and PD and further explored the relationship between lipids and PD-MCI.
Results: PD patients had significantly lower level of lipid panel including TC, TG, HDL-C, Apo A1, LDL-C and Apo B (all p < 0.05). TC, TG, Apo A1 and Apo B levels were independent protective factors (p < 0.05) for PD in the logistic regression model. PD-MCI group had significantly higher mean TC, TG levels and Apo A1 levels compared to PD-NC group. Higher TC, TG and Apo A1 levels were independent risk factors (P < 0.05) for PD-MCI .
Conclusion: We demonstrated that PD patients had significantly lower levels of lipid biomarkers while PD-MCI patients had higher levels of TC, TG and Apo A1. TC, TG and Apo A1 may be useful biomarkers for PD-MCI.
To cite this abstract in AMA style:DX. Deng, LT. Tan. Blood Lipid Biomarkers in Early Parkinson Disease and Parkinson Disease with Mild Cognitive Impairment [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/blood-lipid-biomarkers-in-early-parkinson-disease-and-parkinson-disease-with-mild-cognitive-impairment/. Accessed September 27, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/blood-lipid-biomarkers-in-early-parkinson-disease-and-parkinson-disease-with-mild-cognitive-impairment/