Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: In this study we performed a systematic review and meta-analysis aiming to understand PD-associated iron variations in all brain regions that have been examined, and to evaluate the accuracy of MRI detections as compared to the postmortem results.
Background: Parkinson’s disease (PD) is characterized by excess iron accumulation in substantia nigra, and with reports of iron abnormalities in other brain regions. The iron measurements are mostly using postmortem samples or by live MRI imaging including SWI and R2*. It remains to be clarified in PD with regard to iron changes in brain regions other than substantia nigra, as well as the disparity or consensus between results in postmortem samples or by MRI methods.
Results: The literature search till 19th November 2015 resulted in 4252 articles and 33 articles were eventually identified for data extraction. A total of 10 brain regions were found qualified for data analyses, including substantia nigra, frontal and temporal lobes, nucleus caudatus, globus pallidus, putamen, cerebellum, thalamus, red nucleus, and white matter. The results demonstrated a consistent increase of iron content in substantia nigra in postmortem samples and by SWI and R2* detections. The postmortem measurements also suggested a significant accumulation of iron in putamen, which was confirmed by SWI, but not by R2*. Increased iron deposition was also found in red nucleus as determined by both SWI and R2*, whereas no data available with postmortem samples. Besides, by SWI was also observed significant iron increments in nucleus caudatus and globus pallidus, which however was not indicated in postmortem and R2* measurements.
Conclusions: In conclusion, our results provided an overview of iron deposition in various brain regions of PD patients, and a comparison of outcomes from different detection methods.
To cite this abstract in AMA style:J.Y. Wang, Q.Q. Zhuang, L.B. Zhu, H. Zhu, T. Li, X. Zhang, J.H. Zhu. Brain iron levels in Parkinson’s disease by postmortem and MRI measurements: A systematic review and meta-analysis [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/brain-iron-levels-in-parkinsons-disease-by-postmortem-and-mri-measurements-a-systematic-review-and-meta-analysis/. Accessed September 22, 2023.
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