Objective: To assess the effectiveness of Bright Light Therapy (BLT) in ameliorating symptoms and neuropathology in an α-synuclein preformed fibril (α-syn PFF) induced Parkinson’s disease (PD) mouse model.
Background: The α-syn PFF induced PD mouse model offers a superior simulation of α-syn pathology found in PD patients compared to traditional toxin models. Non-pharmacological treatments like BLT are crucial due to the significant side effects associated with PD drugs.
Method: Mice were injected with α-syn PFF into the striatum using stereotaxic surgery to induce PD. Subjects were then exposed to BLT at 3000-5000 lux for one hour daily over several months. Behavioral and neuropathological assessments were conducted at 1, 2, 4, and 6 months post-injection.
Results: Four months post-injection, α-syn pff mice developed motor deficits and anxiety-like symptoms. Mice treated with long-term BLT maintained motor function and did not exhibit significant anxiety-like symptoms for the six-month duration of the study. BLT reduced α-syn pathology in the substantia nigra and inhibited microglial activation, particularly in the cortex, indicating a suppression of neuroinflammation. Furthermore, BLT mitigated the loss of tyrosine hydroxylase-positive neurons in the nigrostriatal pathway.
Conclusion: BLT emerges as a promising non-pharmacological intervention for PD, offering symptom improvement and neuroinflammation reduction. This study underscores the potential of BLT in PD treatment and sets the stage for future clinical trials.
To cite this abstract in AMA style:
QK. Lv, YR. Sun, F. Wang, CF. Liu. Bright Light Therapy: A Novel Non-Pharmacological Approach to Parkinson’s Disease [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/bright-light-therapy-a-novel-non-pharmacological-approach-to-parkinsons-disease/. Accessed October 15, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/bright-light-therapy-a-novel-non-pharmacological-approach-to-parkinsons-disease/