Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To investigate the concentration of some catecholamines (dopamine, DOPA and DOPAC) in the blood plasma and their ratio to each other depending on sex, form and stage of PD.
Background: There were participated 100 first diagnosed never treated patients with early stage of PD in the study “START-1” funded by Investment and Venture Fund of the Republic of Tatarstan and Fund for the Promotion of the Development of Small Forms of Enterprises in the Scientific and Technical Sphere (2011).
Methods: The analysis of blood samples was performed on the base of the Institution of Russian academy of Science, Institute of Biology and Development.
Results: Results of biochemical analysis were received from 45 patients. Main reasons of analysis failure were conditions counter of cold chain during transportation, vial discontinuity, identification problems.
Ratio of concentrations of dopamine (DA), DOPA and DOPAC in the control group is gender-inclusive and consists of 1:105:64 in average. Patients with PD has increased ratio of DOPA in blood, even not statistically significant. Ratio of concentrations of DA, DOPA and DOPAC in the control group is gender-inclusive and consists of 1:105:64 in average. Patients with PD has increased ratio of DOPA in blood, even not statistically significant.
From the table there is seen that concentrations’ ratio changed due to the stage and form of PD. In patients with akinetic-rigid form (ARF) of PD DOPA and DOPAC reduction is observed while in shaking form (SF) patients this measurements increase, not statistically significant. But significant increase of DOPA ratio is observed in patients with 2 stage SF of PD ones. This tendency of elevation of DA precursor – DOPA and DA metabolite – DOPAC is observed only in patients with SF PD from 1 to 2 stage. Furthermore DA-DOPA-DOPAC ratio decreases from stage to stage only in patients with ARF of PD. Absence of statistical significance may be explained by the insufficient blood sampling.
Conclusions: The cause of such changes is unclear. It is supposed that in SF PD there is some compensatory mechanism is intervened, while in ARF PD this process is not activated, even supressed. Thus the same phenomenology is for some reasons differed in pathomechanism.
To cite this abstract in AMA style:Z. Zalyalova, D. Khasanova. Catecholamines’ concentration ratio in plasma of early diagnosed treatment-naive patients with Parkinson disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/catecholamines-concentration-ratio-in-plasma-of-early-diagnosed-treatment-naive-patients-with-parkinson-disease/. Accessed November 29, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/catecholamines-concentration-ratio-in-plasma-of-early-diagnosed-treatment-naive-patients-with-parkinson-disease/