Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To evaluate motor and non-motor domains, as well as for demographic and disease related characteristics of patients with Parkinson’s disease and the relations with demographic, disease related and clinical variables
Background: Parkinson’s disease, a neurodegenerative disease, is characterized by tremor, rigidity, bradykinesia and postural instabilities in addition to non motor symptoms. Cognitive impairment is one of the common non-motor manifestations in Parkinson’s disease (PD) which has a great impact on patient management.
Methods: This hospital based prospective study was carried out by recruiting 139 PD patients in two major movement disorder clinics in Northern Sri Lanka. Cognitive impairment, motor severity, and disease severity were assessed using Montreal Cognition Assessment (MoCA), UPDRS III and Hoehn and Yahr scale (HY) respectively.
Results: Seventy nine males and 60 females were recruited (n=139). Mean age at disease onset was 62.13 (±9.66) with the disease duration 4.33 (±7.58). Education in years was 10.02 (±3.33). Motor manifestations of PD at the onset was reported by 59 (42.4%) on left upper limbs and on right in 80 (57.6%). Bradykinesia, gait / postural disability, tremor and rigidity score were 16.83 (±8.03), 6.37 (±3.35), 4.04 (±4.18) and 5.37 (±3.57) respectively while the UPDRS III was 34.89 (±16.15). Mean HY score was 2.26 (±0.73); 79.8% (111) of the patients had bilateral disease (HY Score 2-3) while 16.5% (23) presented with unilateral disease (HY score 1-1.5). Tremor was the commonest disability noticed first by 50.4% (70) of the patients. Total score on MoCA was 20.69 (±6.16). There was a negative correlation between motor severity (UPDRS III) and MoCA (p<0.01) while controlling for age at onset, disease duration and education level of the patients.
Conclusions: The negative correlation between UPDRS III and MoCA score suggest poorer cognitive performance is associated with greater motor severity.
To cite this abstract in AMA style:A. Keshavaraj, S. Kunathilagam. Characteristics in relation to demographic, disease related and clinical variables of a cohort of Parkinson’s disease patients from Northern Sri Lanka [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/characteristics-in-relation-to-demographic-disease-related-and-clinical-variables-of-a-cohort-of-parkinsons-disease-patients-from-northern-sri-lanka/. Accessed December 1, 2023.
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