Objective: To investigate the characteristics and brain MRI findings in patient with Parkinson’s Disease

Background: Parkinson’s Disease is a chronic, progressive neurodegenerative disease that is characterized by the loss of dopaminergic function. Brain MRI is used to assess cerebrovascular damage and exlude other possible cause of parkinsonism. There are limited data about brain MRI findings in Parkinson’s Disease

Methods: We perform a cross sectional study at Mohammad Hoesin General Hospital in January until December 2017. There is 16 participants with Parkinson’s Disease according to UK Parkinson’s Disease Society Brain Bank criteria. Brain MRI 1,5 Tesla was used to determine brain images.

Results: Out of 16 participants with Parkinson’s Disease, 3 participants were excluded due to Brain MRI contraindication, brain focal lession, dan fail to get informed consent, There are 13 participants were include (mean age 62 years) in this study, 10 (76.9%) were men and mean MOCA-INA is 17.2 We found that the most common finding in Brain MRI was brain atrophy (46.1%), and followed by white matter hyperintensity (30.8%), cerebral microbleed (23.1%), and lacunar infarct (7,7%). Normal Brain MRI was found in 15.4% cases. The presence of lacunar infarct, cerebral microbleed, white matter hyperintensity, and brain atrophy is hand in hand with cerebral small vessel disease (84.6%).We also found absent swallow tail sign which is a MRI sign of Parkinson’s Disease in 76.9% cases.

Conclusions: This study implicates that MRI findings in patient with Parkinson’s Disease is related to cerebral small vessels disease and absent swallow tail sign. Future studies are needed to evaluate the corellation between Parkinson’s Disease, cerebral small vessels disease, and absent of swallow tail sign.

References: Van der Holst HM, van Uden IWM, Tuladhar AM, et al. Cerebral small vessel disease and incident parkinsonism: The RUN DMC study. Neurology. 2015;85(18):1569-1577. doi:10.1212/WNL.0000000000002082. Oustwani CS, Korutz AW, Lester MS, Kianirad Y, Simuni T, Hijaz TA. Can loss of the swallow tail sign help distinguish between Parkinson Disease and the Parkinson-Plus syndromes? Clin Imaging 2017;44: 66-69.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/characteristics-of-brain-mri-in-patient-with-parkinsons-disease/