MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Chronic wireless streaming of pallidal and cortical recordings in Parkinson’s disease over 1000 hours at home

C. de Hemptinne, R. Gilron, R. Perone, R. wilt, J. Anso, S. Little, I. Bledsoe, M. San Luciano, J. Ostrem, P. Starr (San Francisco, CA, USA)

Meeting: MDS Virtual Congress 2020

Abstract Number: 669

Keywords: Globus pallidus, Motor cortex

Category: Parkinson's Disease: Neurophysiology

Objective: To investigate pallidal and cortical activity associated with motor signs in Parkinson’s disease (PD), by wireless transmission from an implantable bidirectional interface at home over long periods.

Background: Deep brain stimulation (DBS) of the globus pallidus (GP) is an effective treatment for the motor signs of PD, and may be preferred over alternative targets in patients with depression or mild cognitive impairment. Pallidal electrical activity and pallidocortical interactions have been studied intraoperatively or for brief periods in-hospital with externalized leads, but physiology of the pallidum and its cortical interactions have not been studied over long periods in naturalistic environments.

Method: A PD patient with motor fluctuations, tremor and dyskinesias underwent staged bilateral implantation of pallidal and motor cortical quadripolar leads attached to an investigational neural interface capable of both recording and stimulation (Summit® RC+S, Medtronic). Cortical and subcortical signals were recorded simultaneously and chronically while the patient experienced periods of tremor, rigidity and/or dyskinesia. Signals were recorded in a bipolar configuration, sampled at up to 1000 Hz and streamed wirelessly to an external computer. Behavioral state was tracked with a wristwatch-style monitor (Parkinson’s Kinetograph, Global Kinetics Inc.).

Results: Over 1000 hours of data were recorded. GP oscillatory activity at 13 Hz and 25Hz was associated with tremor and rigidity, respectively, while a 7Hz spectral peak in primary sensory cortex emerged during tremor. Dopaminergic medication resulted in a reduction of these oscillations and the emergence of a 75 Hz gamma oscillation in primary motor area. Therapeutic pallidal stimulation reduced the off-state biomarkers, and enhanced the cortical “prokinetic” gamma oscillation while also entraining it at half the stimulation frequency.

Conclusion: Field potentials in pallidum, motor cortex, and sensory cortex offer distinct physiological signatures of specific motor signs. These signals could be used in an adaptive DBS paradigm in order to reduce side effects and improve efficacy.

To cite this abstract in AMA style:

C. de Hemptinne, R. Gilron, R. Perone, R. wilt, J. Anso, S. Little, I. Bledsoe, M. San Luciano, J. Ostrem, P. Starr. Chronic wireless streaming of pallidal and cortical recordings in Parkinson’s disease over 1000 hours at home [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/chronic-wireless-streaming-of-pallidal-and-cortical-recordings-in-parkinsons-disease-over-1000-hours-at-home/. Accessed December 5, 2023.
  • Tweet
  • Email
  • Print

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/chronic-wireless-streaming-of-pallidal-and-cortical-recordings-in-parkinsons-disease-over-1000-hours-at-home/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Patients with Essential Tremor Live Longer than their Relatives
  • Effect of marijuana on Essential Tremor: A case report
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Patients with Essential Tremor Live Longer than their Relatives
  • Carpal Tunnel Syndrome in Patients with Tremor
  • DaTscan in clinical evaluation of Multiple System Atrophy
  • Dropped head syndrome in parkinsonism: Two treatable etiologies not to miss
  • Decision-making process for opicapone’s bedtime regimen
  • Diaphragmatic dystonia in a patient that presents with Meige syndrome and disordered breathing
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2023 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley