Category: Parkinsonism, Others
Objective: We investigated clinical and radiological findings of elder PD patients with the onset of more than 80 years old using clinical examinations, brain CT/MRI findings and DAT and MIBG scintigrams.
Background: The number of patients with Parkinson’s disease(PD) are increasing all over the word due to the aging of the society. According to the national survey, the largest numbers of PD patients are recorded between in 80 to 84 years old in Japan. However the PD patients over 80 years old are exclude in the most of clinical trials or investigations on Parkinson’s disease, so it is difficult to obtain clinical data on PD patients over 80 years old. We investigated clinical and radiological findings of elder PD patients with the onset of more than 80 years old using clinical examinations, brain CT/MRI findings and DAT and MIBG scintigrams.
Method: Patients with PD who were examined and treated at our neurological clinics between January 2018 and December 2022 were listed. The clinical features, ages of onset of the disorder, disability levels of Hoehn & Yahr staging at the consultaion, brain CT/MRI findings and DAT/MIBG scitinograms were investigated.
Results: The number of PD patients who consulted at our clinics were 314 and the number of patients with the onset over 80 is 88, which was 32 % of all PD patients. The disabilities of Hoehn & Yahr stagings at the first consultation are as below, none was on stage 1, 9 were on stage 2, 38 were on stage 3, 33 were on stage 4 and 8 were on stage 5. The mean score of Hoehn&Yahr staging was 3.45 at diagnosis of Parkinson’s disease in neurology clinic. Concerning clinical features, patients with resting tremor were referred to neurology clinic within one year of the disease onset, however the symptoms with akinesia or short steppage without tremor needed 3 to 4 years to be referred to neurologists. On scintigraphical studies cases with akinesia showed lower values than cases with tremor on striatal binding ratio(SBR). MIBG scintigraphy was useful to differentiate cases with vascular parkinsonian cases from idiopathic cases.
Conclusion: The patients with PD developed their disorders over 80 years old is more than 30 % of all PD patients. The mean disability score was more than 3 on Hoehn&Yahr staging. Physician should be aware that a third of PD patients developed their disorders at the age of more than 80 years old.
To cite this abstract in AMA style:M. Nomoto, H. Iwaki, R. Nonaka, N. Yano. Clinical and radiological characteristics of elder patients of Parkinson’s disease with the onset age of more than 80 years old [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/clinical-and-radiological-characteristics-of-elder-patients-of-parkinsons-disease-with-the-onset-age-of-more-than-80-years-old/. Accessed September 28, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-and-radiological-characteristics-of-elder-patients-of-parkinsons-disease-with-the-onset-age-of-more-than-80-years-old/