Objective: Prevalence studies in different parts of the world have shown that Parkinson’s disease is a pathology that has a very important impact in older populations. It is ranked second among the neurodegenerative diseases of the elderly after Alzheimer’s disease. According to WHO estimates of gross prevalence range from 18 per 100,000 people in a population survey in Shanghai, China, to 328 per 100,000 in a door-to-door survey of the Parsi community in Mumbai in India. In Morocco, there is very little published study on the evolutionary profile of patients as well as epidemiological data on Parkinson’s disease.

Background: The objective of our study is to provide an overview of the epidemiological, clinical and management characteristics of idiopathic Parkinson’s disease at the Mohamed VI hospital and university center in Marrakech.

Method: Our study is a cross-sectional, prospective study performed on a series of 100 patients.

Results: The average age of our patients is 62.06 ± 1.065 years. The average age of onset of the disease is 56.195 ± 1.195 years, with men being more affected than women. The side hit first in the majority of cases is the left side. The most abundant form is the akineto-rigid form of the disease with about 73% of our patients suffering from this form of the disease. The most frequent pre-motor syndromes in our series are constipation (36% of cases), hyposmia (24% of cases) and paradoxical sleep disorders (21% of cases). The most common signs are stiffness, tremors (94% of cases), slowness of speech and walking (95% of cases), and disturbances of balance (30% of cases). Most patients in our series are on L-Dopa combined with a dopamine agonist. We found that treatment with L-dopa alone is associated with more motor-related and non-motor complications. The most observed motor complications are fluctuations (54.5%);dyskinesias (23%) and freezing (13%). Women are the most affected.

Conclusion: Compare with literature data, our patients are young. In the majority of cases, L-dopa was introduced in the first few years after the onset of the disease, exposing patients to dyskinesia early in the disease.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-profile-of-idiopathic-parkinsons-disease-in-patients-admitted-to-mohamed-vi-university-hospital-center-of-marrakech/