Session Information
Date: Saturday, October 6, 2018
Session Title: Clinical Trials and Therapy in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: Indications for STN-DBS are assessed based on the clinical symptoms. Our test was a clinical study on the correlation between amplitude and latency of PD SEPs and STN-DBS parameters in the hope of finding a prospective assessment of the efficacy of DBS surgery using objective methods and standards.
Background: Currently, indications for STN-DBS are assessed based on the clinical symptoms and nervous system examinations[13]. There is no objective or effective ancillary examination before surgery to determine the prognosis of patients due to the issues of surgical control and the difficulty in the programming parameters.
Methods: The SEPs(pre-operation med-on) were evaluated.According to the SEP grouping records, comparing patient characteristics, LEDD and STN-DBS parameter.
Results: 1. In the PD patients with more severe clinical symptoms, the LEDD was higher and the SEP N20-P25 component amplitude was higher. 2. A higher amplitude in the N20-P25 component in right hemisphere in the upper limbs and a shorter latency of the N35 and P40 components in right hemisphere were found in patients with higher LEDD after STN-DBS, and this correlated with worse symptom improvement rate and higher program-controlled frequency. 3. The lower the amplitude of the P40-N50 components in right hemisphere in the lower extremities was, the longer the latency of the N35 component was; this correlated with worse symptom improvement rate after STN-DBS and higher programmed intensity. 4. The longer latency of upper limb P25,N35,P40 and lower limb N50 component in left hemisphere showed patients had less pre-operation LEDD,and might to have a great improvement rate of LEDD after 12months, that has significant differences.
Conclusions: An understanding of DBS provides a basis for the study of PD patients with sensory loss ,sensory integration dysfunction and lateralization of seniorimotor control.
To cite this abstract in AMA style:
Z. Jing, Y. Xiaoxue, G. Shuzhao, S. Chunli, L. Zhanhua,. Clinical study on the correlation between Parkinson’s somatosensory evoked potentials and STN-DBS parameters [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/clinical-study-on-the-correlation-between-parkinsons-somatosensory-evoked-potentials-and-stn-dbs-parameters/. Accessed June 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-study-on-the-correlation-between-parkinsons-somatosensory-evoked-potentials-and-stn-dbs-parameters/