Objective: Parkinson is from common disorders of central nervous system and the second disease in neurodegenerative diseases which occurs in 1% of people over the age of 60 and 4% of people over the age of 80. Animal models of disease are very important to study the disease, its molecular mechanism and also behavioral and pathologic changes; therefore, researchers have used laboratory animals as disease models.
Background: Medicinal plants have been considered from ancient times to reduce the symptoms of Parkinson’s disease, however, the effective doses of these drugs are not known. The aim of this study was to compare the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model.
Method: Sixty mature mice in the weight range of 25 to 30g were divided into seven groups: control, Parkinson’s, selegiline, and 50,100, and 200 mg/kg of the hydroalcoholic extract of rosemary. In order to induce Parkinson’s disease, rotenone poison was injected intraperitoneal in 1, 2, and 3 mg/kg doses every other day for 19 days. Control group received only rotenone carrier (dimethyl sulfoxide and sunflower oil) in 48 ml/kg/1h dose. Rearing and Bar behavioral models were used to evaluate the disease.
Results: The hydroalcoholic extract of rosemary in 200 mg/kg dose increased the duration of animal’s presence on 10cm bar significantly and the number of animal attempts in 20 cm glass cylinder which indicate the reduction of Parkinson’s symptoms. Also, this dose increased movement activity of mice significantly.
Conclusion: Rosemary in 200mg/kg dose increased presence time on 10cm bar and animal attempts in a glass cylinder in comparison to a control group which shows a reduction in Parkinson’s behavioral symptom. Also, this dose increased the movement activity of laboratory mice in proportion to the control group. On the whole, it can be concluded that rosemary extract can reduce Parkinson’s behavioral symptom dose-dependently.
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To cite this abstract in AMA style:
M. Modaresi. Comparing the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model in mice [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/comparing-the-effects-of-rosemary-and-selegiline-on-behavioral-symptoms-of-parkinsons-animal-model-in-mice/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/comparing-the-effects-of-rosemary-and-selegiline-on-behavioral-symptoms-of-parkinsons-animal-model-in-mice/