Category: Neurophysiology (Non-PD)
Objective: To analyze a possible correlation between the TH signaling and cellular fate of adult neural stem cells on taiep rats.
Background: H-ABC is a neurodegenerative disease produced by mutations in the TUBB4A gen. At a cellular level, it is characterized by a poor level of myelination at birth and progressive demyelination during lifetime. In some demyelinating diseases, a certain degree of remyelination and generation of new oligodendrocytes has been shown. Moreover, it is well known that thyroid hormones play a crucial role in neurogenesis, both during development and in the adult.
Furthermore, the neural stem cell fate depends on the thyroid hormone signaling. Particularly at the genomic level, thyroid hormones (TH) effects are mediated by their interaction with TH receptors (TRs). In the neurogenic niche of the subventricular zone (SVZ), only the TRa1 isoform is expressed. At binding to the TH, it regulates the cellular destiny of neural stem cells into neural or oligodendrocyte lineage.
Our group recently observed that taiep rat, a spontaneous murine model of H-ABC, shows a hyperplasic SVZ due to an increased number of proliferative neural stem cells.
Method: H serological levels in adult-old rats (nine months) were analyzed by the ECLIA method. TRa1 profile of adult brains was analyzed in coronal sections (30 um) using the IHF technique. Images were acquired using a confocal fluorescence microscope (Zeiss LSM 710) and processed and analyzed with ImageJ and Zen 3.3 (blue) software.
Results: In taiep rats, serological levels of T4 but not T3 or TSH levels showed a significant decrease compared to wild-type rats of the same age. In taiep, the number of TRa1 and SOX2 positive cells on SVZ is higher when compared to control animals.
Conclusion: The hyperplasic SVZ and atrophic striatum observed in taiep rats suggest a disruption of the migration process and probably the reactive neurogenesis previously described by our group. Furthermore, the disruption of TH signaling suggests their implication in neurogenic and migratory processes.
To cite this abstract in AMA style:A. Lopez-Juarez, V. Hernandez, D. Carmona. Correlation between H-ABC and thyroid hormones signaling in the process of adult neurogenesis [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/correlation-between-h-abc-and-thyroid-hormones-signaling-in-the-process-of-adult-neurogenesis/. Accessed September 27, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/correlation-between-h-abc-and-thyroid-hormones-signaling-in-the-process-of-adult-neurogenesis/