Objective: To evaluate the extent of degeneration in dopamine nerve terminal in striatum with the patients with MSA, and compared between subtypes and disease duration in the patients.

Background: MSA, involving neurons both in substantia nigra and striatum, is resulted in reduction of dopamine nerve terminals in striatum. DaT-SPECT employing 123I-Ioflupane, accumulating in dopamine nerve terminal, has enabled to visualize and evaluate the severity of degeneration of nigro-striatal dopamine system.

Methods: 19 patients with MSA; 4 with MSA-P (66.3 +- 3.2 years old, 6.6 +- 1.5 years of disease duration) and 15 with MSA-C (65.9 +- 7.5 years old, 9.9 +- 5.5 years of disease duration) are analyzed in this study. Accumulation of 123I-Ioflupane in striatum was visualized, calculated and evaluated with a software QSPECT with specific binding ratio (SBR) n each subject.

Results: All the patients with MSA-P appeared severe reduction of the signal with no structural configuration of striatum even in short disease duration. In patients with MSA-C, 2 are within normal value in SBR (>4), and all the other showed reduction of SBR count, which correlate weakly with disease duration (coefficient rate R2 is 0.58).

Conclusions: This study with DaT-SPECT in the patients with MSA suggests the degeneration of nigro-striatal dopamine system in MSA-P is faster and severer than in MSA-C.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/dat-spect-in-multiple-system-atrophy-msa/