Objective: To assess the effects of modulation of neck proprioception and deep brain stimulation (DBS) on multifractal characteristics of pallidal local field potentials

Background: The most effective treatment for dystonia is chronic deep brain stimulation (DBS) surgery of the internal segment of globus pallidus (GPi). Modulation of proprioception via neck vibration is also known to alter the symptoms of cervical dystonia. Previously, we have shown that the severity of dystonic symptoms correlated with the width and shape of the multifractal spectrum. The increase in severity scores was accompanied by a decrease in the width of the multifractal spectrum and an increase in its asymmetry.

In this study we investigated whether DBS and vibration would shift multifractal complexity towards the normal state.

Method: The data were recorded during planned neurosurgical operations for implantation of stimulating electrodes (DBS). Four patients underwent externalization of LEAD electrodes for postoperative recording of local potentials (LFP) of the globus pallidus. We calculated the width and asymmetry of LFPs multifractal spectra estimated based on wavelet leaders at rest and during DBS and neck muscles vibration.

Results: In all patients we observed substantial increase of multifractal spectrum width and restoration of its symmetry during both DBS and neck muscles vibration along with clinical improvement. These changes were also characteristic of both internal (GPi) and external (GPe) globus pallidus.

Conclusion: Our data indicate the promise of using multifractal characteristics of pallidal neuronal activity as biomarkers of pathological activity in dystonia and in assessing the effect of different types of therapy.

This study was supported by Russian Science Foundation (23-25-00406).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/dbs-and-neck-muscle-vibration-shift-impaired-pallidal-multifractal-complexity-towards-the-normal-state-in-dystonia-patients/