Category: Dystonia: Clinical Trials and Therapy
Objective: Objective : Author presents a group of patients with generalized dystonia treated with deep brain stimulation (DBS).
Background: 32 patients (18 male, 16 female) age from 6 to 64 (mean 27,3) affected by dystonia were treated with DBS
Method: The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Unified Dystonia Rating Scale (UDRS) and the SF-36 scale before treatment and 9 and 24 months after the procedure. The permanent electrodes were implanted to globus pallidus pars interna (GPi) in whole group of patients. The target was identified with direct and indirect method. Intrasurgical macrostimulation and microrecording were used for neurophysiological evaluation of the target.
Results: No serious morbidity nor mortality were reported in the group. IPG chest hematoma was reported at the region, where internal pulse generator was implanted in one case. One patient died at the follow-up (not related to the DBS procedure or treatment). The most significant factor that influenced efficacy of the treatment was the ethiology of dystonia. The differences between the groups are presented. Better results were achieved in primary and DY-T1 generalized dystonia group
Conclusion: DBS GPi is a safe and effective method of dystonia treatment. Application of this method of treatment in generalized dystonia and dystonia in neurodegeneration with brain iron accumulation is legitimate. The improvement in both functional and quality of life scales were significant in both groups.
To cite this abstract in AMA style:K. Szalecki, T. Kmiec, H. Koziara, T. Mandat. Deep brain stimulation for generalized dystonia [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/deep-brain-stimulation-for-generalized-dystonia/. Accessed December 11, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/deep-brain-stimulation-for-generalized-dystonia/