Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: We assume that the cerebrovascular disease might influence on the course and clinical features of dementia with Lewy bodies (DLB). The aim of this study is to determine the impact of concomitant cerebrovascular disease on diagnosis and management of DLB.
Background: Dementia with Lewy bodies is a progressive neurodegenerative disease characterized by the increasing cognitive decline, parkinsonism, psychiatric disorders, autonomic dysfunction, rapid eye movement sleep behavior disorder. DLB is characterized by gradual onset and steady progression. Apparently the rate of progression depends on the age of onset of the disease, clinical features, concomitant diseases. The majority of elderly have cerebrovascular pathology such as atherosclerosis, amyloid angiopathy, endothelial dysfunction. There are no data about course and clinical features of DLB in patients with cerebrovascular disease.
Methods: We have been studying 50 patients that fulfilled clinical criteria for probable DLB. All subjects are performed both brain MRI on MR tomograph “Signa Excite” with a magnetic field of 1,5 Tesla and volume sphygmography with arterial stiffness measurement as an independent predictor of cerebrovascular morbidity. All participants undergo detailed physical, neurological and neurocognitive examinations including Montreal Cognitive Assessment scale (MoCA), Addenbrooke’s Cognitive Examination (ACE-R), Neuropsychiatric Inventoty-4, University of Miami Parkinson’s disease Hallucinations Questionnaire (UM-PDHQ).
Results: Cerebrovascular dysfunction is observed on the average 2/3 of patients with DLB. It is associated with worse cognitive decline, more rapid progression of the disease. However visual hallucinations are observed less frequently in patients with cerebrovascular disease.
Conclusions: Cerebrovascular dysfunction influences on the course and clinical features of DLB thereby masking the disease. This will help to improve the diagnosis of DLB and increase the sensitivity of the international criteria of DLB.
To cite this abstract in AMA style:A. Chimagomedova, E. Vasenina, O. Levin. Diagnosis and management of dementia with Lewy bodies: Influence of concomitant cerebrovascular disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/diagnosis-and-management-of-dementia-with-lewy-bodies-influence-of-concomitant-cerebrovascular-disease/. Accessed March 2, 2024.
« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/diagnosis-and-management-of-dementia-with-lewy-bodies-influence-of-concomitant-cerebrovascular-disease/