Session Information
Date: Monday, June 5, 2017
Session Title: Surgical Therapy: Other Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To compare local field potentials features in Parkinson´s disease (PD), dystonia and Gilles de la Tourette syndrome (GTS) recorded from the Globus Pallidus internus (GPi).
Background: Local field potentials in the subthalamic nucleus have been recognized as potential biomarkers of PD and other non-parkinsonian movement disorders but the oscillatory activity features in PD compared to other movement disorders such as dystonia, chorea or tics in the GPi has not been ascertained.
Methods: We recorded local field potentials from the GPi in surgically treated patients with deep brain stimulation, in PD (n=2), dystonia (n=7) and GTS (n=2). Spectral power and phase-amplitude coupling characteristics were analyzed.
Results: There are differences in the beta band activity recorded from the GPi in patients with PD, dystonia and GTS. High and low beta band was recorded in the GPi in PD patients, whereas dystonia patients showed only high beta band. Beta band was not present in theGPi in GTS patients. High frecuencies oscillations (HFO) are present in all PD, 28.5 % of dystonia patients and in all patients with GTS.
Conclusions: High frequency oscillations are present in different movement disorders such as PD and GTS but only in some patients with dystonia. Beta band activity and HFO recorded from the GPi of different diseases suggest that oscillatory activity might have a role as specific biomarker of movement disorders.
References: Weinberger M, Hutchison WD, Alavi M, Hodaie M, Lozano AM, Moro E, Dostrovsky JO. Oscillatory activity in the globus pallidus internus: comparison between Parkinson’s disease and dystonia. Clin Neurophysiol 2012;123:358-368.
Dehning S, Feddersen B, Cerovecki A, Botzel K, Muller N, Merhkens JH. Globus pallidus internus-deep brain stimulation in Tourette’s syndrome: can clinical symptoms predict response? Mov Disord 2011;26:2440-2441.
To cite this abstract in AMA style:
M.M. Carmona-Abellan, M. Valencia, J. Guridi, R. Luquin, J. Artieda, M. Alegre. Differences in the oscillatory activity of the globus pallidus in dystonia, parkinson´s disease and gilles de la tourette syndrome [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/differences-in-the-oscillatory-activity-of-the-globus-pallidus-in-dystonia-parkinsons-disease-and-gilles-de-la-tourette-syndrome/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/differences-in-the-oscillatory-activity-of-the-globus-pallidus-in-dystonia-parkinsons-disease-and-gilles-de-la-tourette-syndrome/