Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To investigate the possible role of dopamine transporter (DAT) imaging in patient selection for subthalamic deep brain stimulation (STN-DBS) surgery, we retrospectively investigated the relationship between motor symptoms of patients with Parkinson’s disease (PD) who received bilateral STN-DBS and the specific binding ratio (SBR) on the [123I] FP-CIT SPECT scan.
Background: STN-DBS is a widely accepted functional neurosurgical therapy for advanced PD, especially in patients with motor complications. Imaging studies are required before introducing this therapy. DAT imaging is a powerful tool to visualize dopamine terminals in the striatum. However, the utility of this imaging tool in patient selection for STN-DBS has not yet been studied.
Methods: Twenty-three consecutive patients (9 women, 14 men) who were evaluated as eligible for DBS between October 2013 and October 2014 by using a [123I] FP-CIT SPECT scan and received bilateral STN-DBS were included in the study. A correlation analysis was performed on the SBR, clinical parameters (such as the preoperative Unified Parkinson’s disease Rating Scale (UPDRS) motor scores), improvement ratio of UPDRS motor scores in the dopamine infusion test, and reduction ratio of the levodopa equivalent dose (LED).
Results: The average SBR value was positively correlated with the LED reduction ratio after surgery (r = .422, p = .045) and improvement ratio of UPDRS motor score with levodopa administration before surgery (r = .651, p = .001). The UPDRS motor score for ON-state before surgery showed a negative correlation with the average SBR value (r = -.637, p = .001).
Single regression analysis revealed that the SBR could predict the improvement ratio of the UPDRS motor score before surgery (p = .001, R2 = .423).
Conclusions: These results indicate that the SBR may be a good biomarker to predict the motor response to dopaminergic therapy for patients with PD. Therefore, the [123I] FP-CIT SPECT scan is a useful imaging tool in patient selection for STN-DBS.
To cite this abstract in AMA style:
A. Nakajima, Y. Shimo, S. Sekimoto, K. Kamagata, J. Takayuki, G. Oyama, A. Umemura, N. Hattori. Dopamine transporter imaging predicts motor response to dopaminergic therapy for patients with advanced Parkinson’s disease: Possible role in patient selection for subthalamic deep brain stimulation. [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/dopamine-transporter-imaging-predicts-motor-response-to-dopaminergic-therapy-for-patients-with-advanced-parkinsons-disease-possible-role-in-patient-selection-for-subthalamic-deep-brain-stimu/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/dopamine-transporter-imaging-predicts-motor-response-to-dopaminergic-therapy-for-patients-with-advanced-parkinsons-disease-possible-role-in-patient-selection-for-subthalamic-deep-brain-stimu/