Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The mechanism underlying rest tremor of Parkinson’s disease(PD), while likely differing from those underlying akinesia and rigidity, remains unclear. The objective of this study is to investigate neuroimage profiles of parkinsonism tremor and underling pathophysilogical features.
Background: Various neuroimaging modalities have been used to characterize the brain pathology underlying the motor and non-motor manifestations of PD. However, the results of previous dopaminergic PET/SPECT studies that investigated parkinsonian motor heterogeneity were quite inconclusive. Number and scale of previous FDG studies were limited. These finding require validation by other studies using larger samples and different imaging techniques.
Methods: Resting-state 18F-FDG PET imaging was performed in 136 patients with PD. Among them, 102 PD patients performed 11C-CFT PET imaging at the same time. Patients were divided into tremor dominant(TD) group and akinetic-rigid(AR) group. DAT bindings, PDRP expressions and maps of regional metabolism were compared between groups. UPDRS-III motor sub-scores were used to correlate with DAT bindings ，PDRP expressions and regional cerebral metabolic rate of glucose (rCMRglc).
Results: DAT bindings and PDRP expressions were not significantly different between motor subgroups. Hypermetabolism in bilateral cerebellum/dentate nucleues and contralateral primary sensory cortex was found in TD group compared to AR group, and hypometabolism in contralateral medial frontal gyrus, superior frontal gyrus and cingulate gyrus. For tremor severity, a positive correlation was found with rCMRglc of hypermetabolic regions.
Conclusions: These data showed that dopamine dysfunction is insufficient to explain parkinsonian tremor. Activation of cerebellum/dentate nucleues together with primary sensory cortex may engage in the cerebello-thalamo-cortical circuit, therefore contribute to PD tremor.
To cite this abstract in AMA style:
J. Zhao, L. Li, P. Wu, J. Wang, C.T. Zuo. Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/dopaminergic-and-metabolic-imaging-in-parkinsons-disease-motor-subtypes-and-their-relations-to-parkinsonian-tremor/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/dopaminergic-and-metabolic-imaging-in-parkinsons-disease-motor-subtypes-and-their-relations-to-parkinsonian-tremor/