Category: Surgical Therapy: Parkinson's Disease
Objective: Analyze the effects of DBS on the quality of life of patients diagnosed with Parkinson’s disease.
Background: Parkinson’s disease is a neurodegenerative syndrome due to the decreased dopamine synthesis with great impact on the quality of life of the population and high worldwide prevalence. The pharmacological approach has a good response by diminishing symptoms and maintaining the individual’s well-being, however later on it is common to develop motor complications and gastrointestinal disorders. Thus, surgical treatments turn into options for invasive and efficient approaches, at later stages, such as deep brain stimulation.
Method: A systematic review was performed based on PRISMA Statement. To identify articles, the databases MEDLINE through PubMed and Science Direct, were used on March 3, 2021 and the research strategy was composed by the terms: “Parkinson disease or Idiopathic Parkinson Disease or Primary Parkinsonism” and “Deep Brain Stimulation or Brain Stimulations, Deep” and “Quality of Life of Life Quality or Health-Related Quality Of Life” and “Randomized Controlled Trial”. Randomized clinical trials were included, whose patients underwent surgery for DBS in the STN or GPi and in which the quality of life of PD patients was assessed. The exclusion criteria were studies that did not present DBS as the main intervention or that did not use the PDQ-39 to access the impact of the intervention.
Results: Among 31 studies found, in the database search, 13 met the eligibility criteria, 7 of which were eligible for qualitative analysis. 840 patients were analyzed, 450 underwent DBS and 390 under drug therapy. In general, a statistically significant improvement could be found in the assessment of quality of life in patients undergoing DBS. Weaver et al.(2012) demonstrated an improvement in quality of life in the two groups submitted to DBS after 12 and 24 months (p value statistically significant in all fields). Schuepbach et al.(2013) obtained an improvement of 26% in the DBS group P = 0.02. It is worth mentioning that Rothland et al. (2014) demonstrated that DBS is inefficient in patients with previous cognitive decline.
Conclusion: The analysis of articles revealed that PD patients undergoing DBS had significant improvements in at least one of the areas of PDQ-39. In addition, patients who already had cognitive decline before intervention did not show significant changes in QOL after treatment with DBS.
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To cite this abstract in AMA style:V. Junior, I. Andrade, L. Castanheira, B. Orleans, F. da Silva, L. Magalhães. Effect of deep brain stimulation on quality of life of patients with Parkinson’s Disease [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/effect-of-deep-brain-stimulation-on-quality-of-life-of-patients-with-parkinsons-disease/. Accessed December 5, 2023.
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