Session Information
Date: Sunday, October 7, 2018
Session Title: Quality Of Life/Caregiver Burden in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: This study aims to systematically review the evidence investigating the efficacy of multidisciplinary Parkinson’s disease (PD) care on physical and quality of life outcomes in people with PD.
Background: PD is the second most common neurodegenerative condition in Singapore, resulting in disabling and distressing motor and non-motor symptoms. Although multidisciplinary care have been advocated in recent years, little is known of its efficacy in the long-term management of these patients.
Methods: A targeted search to identify full-text English-language randomized controlled trials (RCTs) published till June 2016 was conducted across 5 electronic databases (Cochrane, PsycInfo, Scopus, Embase, CINAHL). Methodological quality was assessed using the Cochrane “Risk of bias” tool and relevant data was extracted using a standardized form by 2 independent reviewers and compared for accuracy. Mean or standardized mean differences (SMD) were calculated for meta-analyses using fixed or random effects model depending on study heterogeneity.
Results: Six studies (of 1616 screened titles and abstracts), comprising of 637 participants with early to advanced disease (Hoehn and Yahr stage 1 to 4), were included. The meta-analyses demonstrated significant SMD in favour of multidisciplinary care versus non-multidisciplinary controls for quality of life (-0.96; 95% CI, -1.74 to -0.19; p=0.01), disease severity quantified by the Unified PD Rating Scale motor section (MD=-26.03; 95% CI, -47.92 to -4.14, p = 0.02) but not for depression (-0.29; 95% CI, -0.73, 0.16, p=0.21) and caregiver strain (MD=-1.28; 95% CI,-2.56 to 0.00, p=0.05).
Conclusions: This review demonstrated that multidisciplinary care can result in significant improvement in quality of life and PD motor symptoms in people with early to advanced PD, but does not have a significant effect on depression and caregiver strain. The small sample sizes and presence of biases in existing studies highlight the need for further high quality research in this area.
To cite this abstract in AMA style:
S. Balakrishnan, D. Tan. Efficacy of multidisciplinary care in people with Parkinson’s disease: A systematic review and meta-analysis [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/efficacy-of-multidisciplinary-care-in-people-with-parkinsons-disease-a-systematic-review-and-meta-analysis/. Accessed October 10, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/efficacy-of-multidisciplinary-care-in-people-with-parkinsons-disease-a-systematic-review-and-meta-analysis/