Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective:
To study the GI transit time with a novel ambulatory electromagnetic system in PD patients and healthy controls.
Background: The majority of Parkinson’s disease (PD) patients experience gastrointestinal (GI) symptoms, such as constipation. Despite GI non-motor symptoms being highly prevalent in PD, data on objective testing of the GI tract is scarce, especially in the small intestine. Thus, we aimed to study the GI transit time (GITT) during 24-hours monitoring with a novel ambulatory electromagnetic system in PD patients and healthy controls (HC).
Methods:
Twenty-two early-to-moderate stage PD patients (H&Y 2 (1-3), 7 female) and 14 HC (4 female) were included. Transit time in the stomach, small intestine, and the coecum-ascending colonic segment were assessed using the novel 3D-transit system, which monitors an ingested electromagnetic capsule via an abdominal worn receiver station (Motilis Medica SA, Lausanne, Switzerland). Furthermore, the number of and time to first fast movement (passing <1 colorectal segment in ≤2 minutes) and first mass movement (passing ≥1 colorectal segment in ≤2 minutes) were registered.
Results:
The PD group displayed significantly delayed small intestinal (STT) and coecum-ascending transit time (CATT) (p=0.03 and p=0.0063). No significant between-group difference was seen in the stomach (p=0.91). Fast movements were seen in 4 patients and 11 HC (p=0.006) and mass movements were seen in 1 patient and 5 controls (p=0.023).
Conclusions:
This is the first study of GITT in PD patients using the 3D-transit system. Significantly prolonged STT and CATT were demonstrated in the PD group compared to matched controls. No difference was seen in gastric transit time. Furthermore, the patients showed significantly fewer colorectal fast movements and mass movements within 24 hours, indicating generalized functional enteric nervous system involvement in PD.
To cite this abstract in AMA style:
K. Knudsen, T. Fedorova, K. Østergaard, K. Krogh, P. Borghammer. Gastrointestinal transit time in Parkinson’s disease -a novel 3D method [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/gastrointestinal-transit-time-in-parkinsons-disease-a-novel-3d-method/. Accessed December 10, 2023.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/gastrointestinal-transit-time-in-parkinsons-disease-a-novel-3d-method/