Objective: To analysis of glial neurotrophic factor content in blood serum of patients with PD and VP.

Background: Parkinson’s disease (PD)  and vascular parkinsonism (VP) have specific clinical features. Glial neutrophic factor (GDNF) is the main trophic factor in dopaminergic neurons.

Method: We examined 38 patients with PD aged 33 to 66 years (mean age 49.50±5.6), including 20 men and 18 women and 36 patients with VP aged 55 to 76 years (mean age 60.5±7.6), including 20 men and 16 women. The control group consisted of 10 patients without PD, which matched in age and gender. All patients underwent clinical neurological, neuroimaging and biochemical studies. In the dynamics of the level of GDNF was determined by enzyme immunoassay.

Results: The obtained results showed that in the blood serum of patients of the main group, the amount of glial neurotic factor was 47.6±6,5 pg/ml, in the control group 80.668±5.2 pg/ml (p<0.05). In the main group, the content of GDNF was two times lower than in the control group. The serum GDNF level of patients with PD was 41.6±4.2  pg/ml, while the serum level of patients with VP was 53.6±6.5 pg/ml. After 2,0 years in PD patients, the GDNF level was 31.89±3.8 pg/ml, in VP 51,8±5.2 pg/ml, in the control group the GDNF level was 76.7±4.3 pg/ml. GDNF responds to the trophism of dopaminergic neurons, and the death of these neurons depends on the level of the factor. A decrease in GDNF levels aggravates the clinical course of motor and non-motor symptoms of PD.

Conclusion: Glial neurotrophic factor can be considered as a differential marker in Parkinson’s disease and vascular parkinsonism, which is due to the fact that the pathogenesis of the disease is different.

« Back to 2023 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/glial-neurotrophiz-factor-as-a-differential-marker-of-parkinsons-disease-and-vascular-parkinsonism/