Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To assess the associations of hearing function with the progression of parkinsonism in a population-based prospective study.
Background: Hearing impairment is a common symptom among seniors. Several small clinical studies had reported potential associations between poor hearing and parkinsonism.1-5
Method: We included those aged 45-85 years, living in one of 10 Canadian provinces in between 2012-2015 (at the baseline). Parkinsonism was defined as a self-report of parkinsonism diagnosis, in combination with a confirmatory positive symptom screen and/or medication use. Dream enactment behavior (DEB/possible RBD) was screened using the single-question RBD1Q. Associations between hearing and parkinsonism at prodromal and pre-existing stages were assessed cross-sectionally via logistic regression.
Results: Of the 30,097 Candians recruited, 3271 participants screened positive for dream enactment behavior (DEB/possible RBD), 112 had a prior parkinsonism diagnosis at baseline and 58 developed new parkinsonism at 3-year follow-up. Although both dream enactment behavior and prodromal/de-novo parkinsonism was associated with hearing complaints at baseline, neither DEB/possible RBD nor parkinsonism was association with hearing impairment via objective measures.
Conclusion: In this population-based study, we found no link between hearing impairment and parkinsonism or dream-enactment behavior.
References: 1. Shetty K, Krishnan S, Thulaseedharan JV, Mohan M, Kishore A. Asymptomatic hearing impairment frequently occurs in early-onset Parkinson’s disease. Mov Disord 2019;12(2):84. 2. Di Mauro R, Di Lazzaro G, Schirinzi T, Martino F, Mercuri NB. Assessment of Hearing Impairment in Parkinson’s Disease: Implications for Differential Diagnosis and Disease Progression. J Alzheimers Dis Parkinsonism 2017;7(396):2161-0460.1000396. 3. Pisani V, Sisto R, Moleti A, et al. An investigation of hearing impairment in de-novo Parkinson’s disease patients: A preliminary study. Parkinsonism Relat Disord 2015;21(8):987-991. 4. Lai SW, Liao KF, Lin CL, Lin CC, Sung FC. Hearing loss may be a non‐motor feature of P arkinson’s disease in older people in T aiwan. Eur J Neurol 2014;21(5):752-757. 5. Vitale C, Marcelli V, Allocca R, et al. Hearing impairment in Parkinson’s disease: expanding the nonmotor phenotype. Mov Disord 2012;27(12):1530-1535.
To cite this abstract in AMA style:C. Yao, A. Szpindel, A. Pelletier, R. Postuma. Hearing Impairment was not associated with Dream Enactment Behavior and Parkinsonism in the Population: a CLSA Prospective Study [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/hearing-impairment-was-not-associated-with-dream-enactment-behavior-and-parkinsonism-in-the-population-a-clsa-prospective-study/. Accessed December 7, 2023.
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