Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To assess whether longitudinal changes in deep grey matter nuclei iron content are associated with declining motor function in Parkinson’s disease over a period of 18 months.
Background: Iron accumulation plays an important role in neurodegeneration in Parkinson’s disease. Susceptibility weighted imaging (SWI) is a high-resolution MR-based imaging technique for quantifying iron depositions in vivo. Phase images offer greater specificity in quantifying brain iron load. We hypothesised that high-pass filtered phase imaging may be a useful monitoring tool for longitudinal clinical characterization of PD, and we sought to investigate the clinical associations of iron depositions in deep grey matter nuclei.
Methods: We evaluated forty-two PD subjects and six age and gender matched healthy volunteers (HV) longitudinally with high-pass filtered phase imaging at baseline and after 18 months. Average phase shifts (radians) in the caudate nucleus, putamen, globus pallidus, substantia nigra (SN) and dentate nucleus (DN) were analysed using SPIN software. Longitudinal changes of bilateral radians (Δ radians) were calculated by subtracting baseline values from follow up values. Parametric correlations of regional Δ radians were conducted with Δ UPDRS part III, tremor and bradykinesia-rigidity sub-scores. Correlations were considered significant only if p f p<0.05 following Benjamini-Hochberg FDR adjustments.
Results: PD patients showed significant higher radians in the SN (p<0.001) after 18 months, without significant change in controls. No significant longitudinal iron deposition changes were found in striatal and dentate nuclei. Δ SN radians positively correlated with Δ UPDRS-III (r=0.650, p<0.001) and bradykinesia-rigidity subscores (r=0.523, p=0.001). In addition Δ DN correlated with tremor subscores (r=0.464, p=0.008).
Conclusions: Our results show that high-pass filtered phase imaging might offer an interesting monitoring tool to evaluate longitudinal progression of motor severity and clinical phenotypes in PD, and could be useful to assess the effect on these structures of iron chelation therapies.
To cite this abstract in AMA style:
A. Martin-Bastida, N. Lao-Kaim, Y. Xing, C. Loane, A. Roussakis, S. Schwarz, N. Valle-Guzman, P. Mahlknecht, X. Li, G. Paul-Visse, H. Widner, M. Politis, T. Foltynie, R. Barker, D. Auer, P. Piccini. High-Pass Filtered Phase MR Imaging to Detect Longitudinal Motor Associations of Iron Accumulation in Parkinson’s Disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/high-pass-filtered-phase-mr-imaging-to-detect-longitudinal-motor-associations-of-iron-accumulation-in-parkinsons-disease/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/high-pass-filtered-phase-mr-imaging-to-detect-longitudinal-motor-associations-of-iron-accumulation-in-parkinsons-disease/