Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To investigate the neuroimaging marker that predict the conversion of mild cognitive impairment (MCI) to dementia in Parkinson’s disease (PD) patients.
Background: Patients with PD often show MCI. Some of them may develop dementia as the disorder progresses. In the accompanying paper, we showed that the glucose uptake in the posterior parietal cortex (PPC) is a useful marker for dementia in PD.
Methods: We performed [18F]FDG positron emission tomography for 38 patients with PD and MCI (PD-MCI), and then, followed them for 5 years (5.1±1.2 years, mean±SD). Regional patterns of [18F]FDG uptake in the cerebral cortex of PD-MCI was compared with those of PD patients with dementia (PD-D, n= 23, age 77.6±6.5 years) and PD without dementia (PD-ND, n= 12, age 71.8±8.0 years). Glucose uptake in the PPC, expressed as % of glucose uptake of the whole brain, was compared between the two groups: PD-MCI patients converted to PD-D and those not converted to PD-D.
Results: Glucose uptake in the PPC was 90.4±5.2 in the PD-MCI, significantly different from that in the PD-ND (99.1±2.8; p<0.001) or from that in the PD-D group (86.5±3.6; p<0.001). Among 38 patients with PD-MCI, 24 patients were converted to PD-D (i.e., converter) while 14 patients remained as PD-MCI (i.e., non-converter) over the 5-year of observation period. Glucose uptake in the PPC was significantly lower in the converters compared to the non-converters (88.4±5.4 in converter vs 94.2±2.3 in non-converters; p<0.001). Glucose uptake in the PPC of converters was not significantly different from that of the PD-D group. Glucose uptake in the PPC of non-converters was significantly lower than that of PD-ND (99.1±2.8; p=0.001 vs non-converters).
Conclusions: Our data showed that glucose uptake in the PPC separated the converters from the non-converters. We conclude that the glucose uptake in the posterior parietal cortex would be a useful neuroimaging marker that predicts the progression of PD-MCI to PD-D.
To cite this abstract in AMA style:KW. Park, NR. Choi, JH. Ko, SJ. Kim, SJ. Chung, CS. Lee. Hypometabolism of the posterior parietal cortex in Parkinson’s disease with mild cognitive impairment predicts the conversion to dementia: 5-year longitudinal observations [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/hypometabolism-of-the-posterior-parietal-cortex-in-parkinsons-disease-with-mild-cognitive-impairment-predicts-the-conversion-to-dementia-5-year-longitudinal-observations/. Accessed December 7, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/hypometabolism-of-the-posterior-parietal-cortex-in-parkinsons-disease-with-mild-cognitive-impairment-predicts-the-conversion-to-dementia-5-year-longitudinal-observations/