Session Information
Date: Monday, September 23, 2019
Session Title: Genetics
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: The aim of the study is to analyze the genetic alterations in SNCA gene and dopamine transporter in 22 PD patients of Coimbatore population.
Background: Parkinson’s disease (PD) is a progressive motor system disorder, which affects the substantia nigral area that controls balance and movement. Studies have shown that the protein α-synuclein (SNCA), a common biomarker regulates the neurotransmitter release and supply of dopaminergic neurons inside the brain.
Method: PD subjects were interviewed using a standard questionnaire and informed consent has been obtained from the patients. Molecular analysis was carried out by PCR and sequencing in both control and PD patients. Even dopamine transporter – single-photon emission computed tomography (DAT-SPECT) imaging was performed in PD patients with equal control subjects. The significance rate has been measured through statistical mean.
Results: In the results we observed a point mutation in the SNCA gene also with striatal binding defect in SPECT imaging.
Conclusion: From the results, the study elucidates the correlation between SNCA and dopaminergic binding rate in PD. In conclusion, the correlation is generally observed during the early onset of PD.
To cite this abstract in AMA style:
D. Venkatesan, B. Vellingiri. Identification of genetic alterations and SNCA mutation in Parkinson’s disease patients of Coimbatore Population, India [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/identification-of-genetic-alterations-and-snca-mutation-in-parkinsons-disease-patients-of-coimbatore-population-india/. Accessed May 24, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/identification-of-genetic-alterations-and-snca-mutation-in-parkinsons-disease-patients-of-coimbatore-population-india/