Category: Surgical Therapy: Parkinson's Disease
Objective: The aim of our study is to evaluate the impact of the deep brain stimulation (DBS) electrode position within the subthalamic nucleus on gait in patients suffering from Parkinson’s disease.
Background: DBS impacts both motor and non-motor symptoms in patients with Parkinson’s disease. Subthalamic nucleus (STN), common DBS target, has its own somatotopic organization. Position of DBS electrode active contact in different parts of STN provides different results on Parkinson’s disease symptoms.
Method: Our study is based on the results of the study of Navratilova et al . Their results suggested positive effect of DBS on some gait parameters in patient with Parkinson‘s disease. In our study the coordinates of the DBS active electrode were localised and then the correlation between the location and the change of gait parameters before DBS, after the start of neurostimulation, and 3 months after neurostimulator activation, were calculated. Parameters step length and stance phase duration in different speed were assessed.
Results: Data from 20 patients were obtained. Location of DBS electrode active contact had no statistically significant impact on the parameter step length. After start of the stimulation more dorsal stimulation position (Z-axis) was associated with increased stance phase duration in various speeds. Also more medial stimulation (X-axis) was associated with increased stance phase duration. After 3 months more dorsal, medial and anterior (Y-axis) stimulation was associated with increased stance phase duration
Conclusion: Position of the DBS electrode in STN has impact on change of some gait parameters in patients with Parkinson’s disease.
References:  Navratilova et al., Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients Front Neurosci 2020 Aug 14;14:814. doi: 10.3389/fnins.2020.00814.
To cite this abstract in AMA style:J. Bardoň, D. Burďáková, J. Valošek, D. Krahulík, P. Otruba, P. Kaňovský, M. Nevrlý. IMPACT OF DEEP BRAIN STIMULATION ELECTRODE POSITION ON GAIT IN PATIENTS WITH PARKINSON’S DISEASE [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/impact-of-deep-brain-stimulation-electrode-position-on-gait-in-patients-with-parkinsons-disease/. Accessed September 23, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/impact-of-deep-brain-stimulation-electrode-position-on-gait-in-patients-with-parkinsons-disease/