Objective: Quantify changes in gait parameters in patients with Parkinson’s disease (PD) who underwent autologous peripheral nerve grafts implantation (surgical deployment of the Schwann cells obtained from sural nerve) into the substantia nigra at the time of deep brain stimulation (DBS) surgery {DBS-plus}. Our goal was to determine the effects of DBS plus on gait parameters and to see if DBS plus has long-term (two-year follow-up) benefits on disease severity and mobility.

Background: Schwann cells are abundant in peripheral nerve tissue and transdifferentiate after injury into “repair cells.” Peripheral nerve graft delivery to the substantia nigra at the time of DBS surgery is feasible and safe based on the results of our initial pilot study 1. Assessment of long-term improvement in gait parameters is an important aspect to study the benefits of DBS-plus.

Method: Standard DBS surgery targeting the bilateral globus pallidi was performed in 8 study participants. We evaluated the effects of DBS-plus on gait and disease severity at the baseline and at the 2-year follow-up after surgery. Various gait parameters (gait velocity, step length, cadence, single support and double support) were measured with Gaitrite along with UPDRS and H&Y scores, before and after DBS plus, during the OFF (medication OFF/stimulation OFF) stage. We present the data for 8 patients who have completed the two-year follow-up in the study.

Results: Severely affected individuals with Hoehn and Yahr (H&Y) of >/=3 (N=5) showed improvements in both spatial (step length, gait velocity) and temporal measures (cadence) of gait, whereas less severely affected individuals (H&Y) of <3 (N=3) did not show these improvements. Changes in gait parameters persisted even after 2 years of DBS-plus implantation. Severely affected group also showed reduction in H&Y and UPDSR (Part III) scores. Unlike previous studies, changes in temporal (cadence) measures were observed for gait over the two years.

Conclusion: With the preliminary data, we observed improvement in gait and disease severity parameters, especially for individuals who were most severely affected in the group. Interestingly, the observed changes persisted two years post-surgery. DBS Plus might prove to be an effective intervention in long-term changes of disease and gait symptoms in PD patients.

References: 1. van Horne CG, Quintero JE, Slevin JT, Anderson-Mooney A, Gurwell JA, Welleford AS, Lamm JR, Wagner RP, Gerhardt GA. Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson’s disease during deep brain stimulation surgery: 1-year follow-up study of safety, feasibility, and clinical outcome. J Neurosurg. 2018 Feb 16:1-12. [Epub ahead of print]. 2. Roper JA, Kang N, Cauraugh JH, Okun MS, Hass CJ. Deep brain stimulation improves gait velocity in Parkinson’s disease: a systematic review and meta-analysis. J Neurology 2016 Jun; 263(6): 1195-203.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/improvements-in-gait-deficits-with-peripheral-nerve-grafts-implanted-into-the-substantia-nigra-in-patients-with-parkinsons-disease-during-deep-brain-stimulation-surgery-2-year-follow-up-stud/