Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To identify a dominant parameter of galvanic vestibular stimulation (GVS) which affects the neural responses for the relief of parkinsonian symptoms
Background: Typical parkinsonian symptoms are akinesia, rigidity, tremor and postural instability. According to multiple studies, these symptoms of Parkinson’s disease (PD) might be relieved by galvanic vestibular stimulation (GVS). However, it is still elusive which parameter in GVS is a dominant factor to influence the neurological mechanism during the relief. Here, we investigated the neuronal effects by strength and rate of stimulation, which are the core factors to generate GVS.
Methods: Twenty three neurons in the vestibular nucleus (VN) from fifteen guinea pigs (490-594g) were stimulated by GVS and their responses were filtered and recorded (Plexon, US). GVS was designed as three types; 100μA DC with a 60-second resting period (type I), 100μA DC with a 120-second resting period (type II), and 200μA DC with a 60-second resting period (type III). The effect by strength or rate was induced by increasing the DC amplitude or the interval of resting period, respectively. Using the firing rates by each type of stimulations, three responding slopes were calculated. The inner angles between the slopes from type I and II indicated the effect by rate while that between the slopes from type I and III was for the effect by strength.
Results: The inner angles indicated that either modified rate or strength of stimulation affected its relevant neuronal responses, 52.2% and 65.2% by the rate and the strength, respectively. Based on the statistical test, however, the effect by the rate was little (p=0.34). On the other hand, that by the strength induced a significant change in the neuronal responses (p=0.04).
Conclusions: The strength influenced on the pattern of the neuronal response more than the rate.
References: This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2010-0020163 & NRF- 2016R1D1A1B03930657).
To cite this abstract in AMA style:G.T. Kim, K.S. Kim, S.M. Lee. Investigation on the neural effects by differing the parameters of electrical stimulation for the relief of parkinsonian symptoms [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/investigation-on-the-neural-effects-by-differing-the-parameters-of-electrical-stimulation-for-the-relief-of-parkinsonian-symptoms/. Accessed December 1, 2023.
« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/investigation-on-the-neural-effects-by-differing-the-parameters-of-electrical-stimulation-for-the-relief-of-parkinsonian-symptoms/