Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To assess distal functional gastrointestinal (GI) symptoms and their connection to fecal microbiota (FM) in Parkinson (PD) patients.
Background: The majority of PD patients suffer from GI symptoms of which usually constipation is mentioned as the most prominent. Constipation is one of the strongest risk factors for PD, and recently also irritable bowel syndrome (IBS) was linked to PD. Gut microbiota alterations were recently described in PD. We wanted to assess functional GI symptoms in PD and their possible connection to other non-motor symptoms (NMS) and FM.
Methods: This case-control study compared 74 patients with a diagnosis of PD according to the Queen Square Brain Bank criteria with 75 sex- and age-matched control subjects without any signs of parkinsonism or potential premotor symptoms. The prevalence and overall severity of NMS was assessed using the NMS Questionnaire (NMSQuest). Distal functional GI symptoms were assessed using the Rome III questionnaire. FMs were compared by pyrosequencing of the V1-V3 regions of the bacterial 16S ribosomal RNA gene.
Results: IBS was significantly more prevalent in PD patients than in controls (24.3 % vs. 5.3 %; p=0.001). The most common subtype in PD patients was mixed IBS (IBS-M; 14.9 %). Prevalence of constipation-predominant (IBS-C) and diarrhea-predominant IBS (IBS-D) in PD patients were 6.8 %, and 1.4 %, respectively. In addition, 12.2 % of PD patients and 6.7 % of controls suffered from functional constipation (FC) (p=0.072).
Parkinson (n=74) | Control (n=75) | p-value | |
IBS | 24.3 % | 5.3 % | 0.001 |
IBS-C | 6.8 % | 2.7 % | 0.276 |
IBS-D | 1.4 % | 0.0 % | 0.497 |
IBS-M | 14.9 % | 2.7 % | 0.009 |
FC | 12.2 % | 4.0 % | 0.078 |
Conclusions: The high prevalence of PD patients who fulfill the criteria for IBS, and IBS-M being the most common subtype indicates that, in addition to constipation, patients may suffer from a broader spectrum of distal GI symptoms. A more systematic assessment of functional GI symptoms could add value to assessment of NMS in PD. The lower abundance of Prevotella bacteria in IBS+ may indicate that microbiota play a role in GI symptoms of PD patients.
To cite this abstract in AMA style:
T. Mertsalmi, V. Aho, P.A.B. Pereira, L. Paulin, E. Pekkonen, P. Auvinen, F. Scheperjans. Irritable bowel syndrome is more prevalent than functional constipation in Parkinson’s disease: Clinical spectrum and changes in gut microbiota [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/irritable-bowel-syndrome-is-more-prevalent-than-functional-constipation-in-parkinsons-disease-clinical-spectrum-and-changes-in-gut-microbiota/. Accessed December 10, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/irritable-bowel-syndrome-is-more-prevalent-than-functional-constipation-in-parkinsons-disease-clinical-spectrum-and-changes-in-gut-microbiota/