Objective: To study the performance of MRI in patients with Parkinson’s disease, depending on the stage of the disease.

Background: Steadily progressive chronic neurodegenerative disease of the central nervous system – Parkinson’s disease (PD) – has traditionally been seen as pathology predominantly affects the motor or motor area.

Methods: Using magnetic resonance imaging were examined 49 patients with Parkinson’s disease. Stage of disease as determined by a scale Hyun and Yara, was represented in this group of patients as follows: Stage 1 – 12 people, 2,0 stage – 13 people, 2,5 stage – 16 people, 3,0 Step – 8 people. In seven patients from this group were diagnosed with dementia. With the development of the disease was marked deterioration of the general condition of the cognitive functions, which in some cases has reached the level of dementia. On the 2 stages of the disease pattern changes significantly. Cognitive impairment is detected only in 24% of subjects, mild cognitive impairment was found in 72%. 4% of patients on two stages of the disease in accordance with ICD-10, was diagnosed with dementia. At the third stage of the disease dementia it was established in 57% of cases, and the lack of cognitive impairment was detected in 14% of subjects.

Results: Analysis of the data revealed that significant (p <0.01) were found differences in the position of atrophic changes between a group of patients diagnosed with dementia and patients, the clinical picture of the disease which has been complicated by dementia. In patients with dementia there was a relatively high degree of atrophy in the temporal and occipital lobes relative to patients without dementia. Three of the seven patients with dementia marked by moderate, and one – severe degree of atrophy in the frontal, parietal-temporal areas of the brain hemispheres. Patients with dementia and atrophy in the temporal, occipital and frontal lobes of the brain with the help of experimental psychological studies have revealed a violation of memory, reduced visual-spatial perception, increasing the number of proofreading errors in the performance of the sample and Kraepelin table, brief assessment scale mental status.

Conclusions: Thus, the results suggest an increase in the role of cortical structures in the development of cognitive impairment in the later stages of Parkinson’s disease.

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/magnetic-resonance-characteristic-of-parkinsons-disease-based-on-the-presence-of-cognitive-impairment/