Objective: We aimed to estimate the MCIDs of HFS-30 and HFS-7, and factors associated with the MCID along with baseline and change score of HFS-30 at 1 month of follow-up (F/U).
Background: Hemifacial spasm (HFS) affects health-related quality of life (HRQoL). The HFS-30 and HFS-7 questionnaires assess the HFS HRQoL. Their minimally clinical important difference (MCIDs) have never been estimated.
Method: We collected data prospectively at one referral center Botulinum toxin (BoNT) clinic between 2022 and 2023 in all HFS patients aged ≥ 18 years. We collected HFS scores, Samsung Medical Center (SMC) grade, PHQ-9 and a patient-reported HRQoL global rating scale of change (GRS) at pre-treatment baseline, followed by GRS and/or HFS scores at 2-day intervals until 2 weeks and 1-month F/U. The first F/U visit with patient-reported minimal improvement determined the MCID.
Results: 112 patients were recruited. The median age and HFS duration were 62.8 years (IQR 56.6, 69.3) and 10 years (IQR 4, 17), respectively. The MCID of HFS-30 and HFS-7 by the was -4.46 points (95%CI -5.41, -3.65) and -2.63 points (95%CI -3.33, -1.92), respectively. Moderate-to-severe depression patients reported significantly higher MCID than those with none-mild depression (p<0.001). Age and PHQ-9 were significantly associated with baseline HFS-30, and these along with HFS clinical severity were significantly associated with change score at 1-month F/U (all p<0.05).
Conclusion: The MCIDs of HFS-30 and HFS-7 were -4.46 and -2.63 points, respectively. MCID and HFS-30 scores were associated with age, depression, and clinical severity.
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To cite this abstract in AMA style:
N. Inthapong, W. Saengphatrachai, Y. Pitakpatapee, N. Rattanathamsakul, P. Sirvanitchapoom. Minimally Clinical Important Differences of Hemifacial Spasm Score-30 (HFS-30) and Hemifacial Spasm Score-7 (HFS-7) for Patients with Hemifacial spasm [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/minimally-clinical-important-differences-of-hemifacial-spasm-score-30-hfs-30-and-hemifacial-spasm-score-7-hfs-7-for-patients-with-hemifacial-spasm/. Accessed October 5, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/minimally-clinical-important-differences-of-hemifacial-spasm-score-30-hfs-30-and-hemifacial-spasm-score-7-hfs-7-for-patients-with-hemifacial-spasm/