Session Information
Date: Tuesday, June 6, 2017
Session Title: Therapy in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: The aim of study is to find brain stimulation areas showing more effective response.
Background: Freezing of gait (FOG) is frustrating problem in Parkinson’s disease (PD). There is no effective treatment.
Methods: Twelve patients with PD were participated. All of them had FOG. Repetitive transcranial magnetic stimulation (rTMS) were applied to brain for two consecutive days. We measured the number of steps, completion time and freezing episodes during the stand-walk-sit (SWS) test before and after intervention. We also tested freezing episodes on two FOG provoking tasks before and after rTMS treatment. Two stimulation sites of their brain were pseudo-randomly assigned: the motor cortex (MC) or supplementary motor area (SMA). Patients were blinded as to which site was selected. Four rTMS blocks were delivered, each 10 minutes apart in each day. One block consisted of 15 25 Hz of 1-second duration with an intertrain interval of 10 seconds at 100% resting motor threshold.
Results: There was a trend that the reduction of freezing episodes on rapid full turn test in SMA stimulation than in MC (p=0.071). In paired test, FOG was significantly improved in SMA stimulation (ps < 0.05), whereas was not in MC stimulation.
Conclusions: Our study suggests that SMA stimulation may be a more appropriate target in PD patients with FOG.
To cite this abstract in AMA style:
S.Y. Kang, S.J. Kim. More effective rTMS site for the freezing of gait in Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/more-effective-rtms-site-for-the-freezing-of-gait-in-parkinsons-disease/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/more-effective-rtms-site-for-the-freezing-of-gait-in-parkinsons-disease/