Objective: In the current study we have evaluated possible synergistic neuroprotective effect of two Poly-Phenols from Curcumin and Mucuna Prurience. The combine treatment of Curcumin and Methanolic Extract of Mucuna prurience seed was explored for their possible neuroprotective role against rotenone induced behaviourial, mitochondrial and oxidative dysfunction in mice model of Parkinson’s disease.

Background: Curcumin and extract of Mucuna prurience are natural polyphenolic, highly effective bioactive compounds. Mucuna prurience is popular Indian medicinal plant which has long been used in ayurvedic system of medicine. They revealed numerous biological and pharmacological activities with effective antioxidant, cardiovascular disease, anticancer, anti-inflammatory effects, antidiabetic, anticholestrolemic, aphrodisiac and neuroprotective properties in cell cultures and different animal models.

Methods: Chronic 21 days administration of rotenone (1 mg/kg i.p.) significantly reduced behavioral parameter (Memory, learning and locomotor activity), antioxidant status (Decreased activity of lipid peroxidation, superoxide dismutase, catalase and reduced glutathione level) and mitochondrial Complex-II-Succinate Dehydrogenase (SDH), Complex III- MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyl-H-tetrazolium bromide) enzymes activities as compared to normal group of mice.

Results: Combination of Curcumin and extract Mucuna prurience treatment for 21 days showed significant (P<0.001) improvement in behavior parameter, oxidative damage and mitochondrial enzyme complex activities as compared to rotenone-treated (negative control) group. The result of present investigation shows that Curcumin and extract of Mucuna prurience in combination restored the motor deficiency and increases the antioxidant and neuroprotective activities.

Conclusions: The finding of present study demonstrates that the role of both Curcumin and extract of Mucuna prurience potential against rotenone-induced Parkinson’s in mice and could serve as therapeutic strategies for the management and prevention of Parkinson’s Disease.

References: 1. Phom L. et al., 2014. Curcumin neuroprotective efficacy in Drosophila model of Idiopathic Parkinson’s disease is phase specific; implication of its therapeutic effectiveness. Rejuvnation Research 17, 481-489. 2. Bala V. Manyam, Muralikrishnan Dhanasekaran 2004. Neuroprotective Effects of the Antiparkinson Drug Mucuna pruriens. phytotherapy research, 18, 706–712. 3. Ramkumar M. et al., 2017. Neuroprotective effect of Desmethoxycurcumin, a natural derivative of curcumin on rotenone induced neurotoxicity in SH-SY 5Y neuroblastoma cell. BMC complementary and alternative medicine, 17 (217), 1-11.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-effects-of-a-combination-of-curcumin-and-mucuna-prurience-in-rotenone-induced-mice-model-of-parkinsons-disease/