Session Information
Date: Tuesday, June 21, 2016
Session Title: Genetics (NON-PD)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: Analyze the Ninjurin 1 gene single nucleotide polymorphisms in leprosy patients from south India, and the role of the gene in the nerve damage.
Background: Leprosy is a chronic granulomatous infection caused by Mycobacterium leprae, and obligate intracellular bacillus, that attacks cutaneous tissue and peripheral nerves producing skin lesions, nerve degeneration, anesthesia, infection and deformities.
Methods: A total of 106 subjects (Male: 65 Female: 41) with an average age of 37.05 ± 8.62 years Leprosy of experimental subjects with age and gender-matched control subjects were recruited. Genotyping was done by polymerase chain reaction/restriction fragment length polymorphism (PCR–RFLP–SNPs Confirmation for Sequence) methods.
Results: Leprosy patients with the CC genotype (ala/ala) had a higher risk of developing nerve disability when compared those carrying the AA genotype (asp/asp) and the variation observed were statistically significant (P< 0.05).
Conclusions: Present study revealed that D110A Codon variation may be a risk of nerve damage among leprosy patients in Tamilnadu, South India.
To cite this abstract in AMA style:
A. Sundaramoorthy, S. Keshavarao, A. Valsala Gopalakrishnan. Ninjurin 1 gene D110a single nucleotide polymorphism as a genetic marker for nerve damage leprosy patients from South India [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/ninjurin-1-gene-d110a-single-nucleotide-polymorphism-as-a-genetic-marker-for-nerve-damage-leprosy-patients-from-south-india/. Accessed May 21, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/ninjurin-1-gene-d110a-single-nucleotide-polymorphism-as-a-genetic-marker-for-nerve-damage-leprosy-patients-from-south-india/