Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Background: Parkinson’s disease is a surprising heterogeneous neurodegenerative disorder. Early onset Parkinson’s disease (EOPD) and late onset Parkinson’s disease (LOPD) were reported to present with differences in not only clinical but also pathophysiological features. However, the neural mechanism underlying these disparate subtypes was still unclear.
Methods: This study aims to mapping functional connectivity (FC) patterns of early-stage drug-naïve EOPD and LOPD in two subgroups of 18 patients matched for disease duration and severity, relative to 36 age- and sex-matched healthy controls. Magnetic resonance imaging (MRI) was used to assesse atrophy and resting-state FC focusing on striatal subregions.
Results: Compared with healthy controls, both PD subgroups showed FC alterations in cortico-striatal and cerebello-striatal loops but with different patterns. EOPD patients showed more widespread increased FC changes in sensorimotor-striatal circuit, olfactory-striatal and cerebello-striatal loops, while LOPD patients were evidenced with prominent increased FC in cerebello-striatal circuit and decreased FC in orbitofrontal-striatal loop. In addition, UPDRSIII scores negatively correlated with the increased FC in sensorimotor-striatal circuit (r = -0.571, p = 0.013) in EOPD patients, while negatively correlated with the increased FC within cerebello-striatal circuit (r = -0.478, p = 0.045) in LOPD patients, suggesting that increased FC is here likely reflect compensatory mechanism.
Conclusions: FC changes in EOPD and LOPD share common features and differences and the underlying patterns of compensatory mechanism for the defective basal ganglia may differ between EOPD and LOPD, which probably correlated to a distinct distribution of pathological changes. Our insights into the onset-related subtypes of PD and its disruptive functional connectivity pattern will be valuable for improving our understanding of PD pathogenesis.
To cite this abstract in AMA style:Y. Hou, J. Yang, C. Luo, R. Ou, W. Song, Q. Gong, H. Shang. Onset-related subtypes of Parkinson’s disease differ in the patterns of striatal functional connectivity: A resting-state functional MRI study [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/onset-related-subtypes-of-parkinsons-disease-differ-in-the-patterns-of-striatal-functional-connectivity-a-resting-state-functional-mri-study/. Accessed September 28, 2023.
« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/onset-related-subtypes-of-parkinsons-disease-differ-in-the-patterns-of-striatal-functional-connectivity-a-resting-state-functional-mri-study/